http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1781646-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6a5e0fc0860994733913938896f87f4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-16 |
| filingDate | 2005-06-17^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-08-18^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a4f810dfcde86801e93358d366a2ed0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_802a5f403a0c52285bdded90e3c2b652 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b2f7832df32a5a8f049b77f03964f9e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cfaa52cd6d0e3c68c45f52426caf531 |
| publicationDate | 2010-08-18^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1781646-B1 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF 11-(4-[2-(2-HYDROXYETHOXY)ETHYL]-1-PIPERAZINYL)DIBENZO[b,f][1,4]THIAZEPINE |
| abstract | Disclosed is a process for the preparation of l l-(4-[2-(2-hydroxyethoxy)ethyl]-l- piperazinyl)-dibenzo[b,f][l,4]thiazepine. In the process, low-priced 2,2'-dithiosalicylic acid as starting material is subjected to bond formation reaction with l-chloro-2- 5 nitrobenzene in a basic aqueous solution, a nitro group reduction reaction is conducted, cyclization and chlorination reactions are simultaneously carried out in the presence of a equivalent amount of halogenating agent, a reaction with piperazine is continuously conducted without separation, and a reaction with 2-haloethoxyethanol is conducted, thereby it is possible to economically producing Quetiapine, that is, l l-(4-[2-(2- 10 hydroxyethoxy)ethyl]-l-piperazinyl)-dibenzo[b,fj[l,4]thiazepine, in an environmentally friendly manner. Particularly, the process is advantageous in that economic efficiency is assured because of use of the low-priced starting material, use of an organic solvent is minimized because a reaction is conducted in an aqueous solution, and it is possible to achieve the environmentally friendly and economical process having high commercial 15 usefulness because the number of reaction steps of the process is reduced and because generation of acidic waste is minimized. |
| priorityDate | 2004-06-23^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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