http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1874760-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2006-03-17^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19a9c9a28f3b7f0d8a2d4256de0c5526 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e10e9cf4ca25c598d57e47a807f594db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_638241c54febb2b9cbe7b107c8308709 |
| publicationDate | 2008-01-09^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1874760-A1 |
| titleOfInvention | (lh-ind0l-7-yl)-( (pyrimidin-2 -yl-amino) methanone derivatives and related compounds as igf-rl inhibitors for treating cancer |
| abstract | The invention relates to compounds of formula I, wherein Ar represents a mono or binuclear aromatic homo- or heterocycle, having 1 - 4 N, O- and/or S-atoms and 5 - 10 structural atoms which can be substituted, one, two or three times by carboxylic oxygen, HaI1 A, OH, OA, NH2, NHA, NA<SUB>2</SUB>, NO<SUB>2</SUB>, CN, OCN, SCN, COOH, COOA, CONH<SUB>2</SUB>, CONHA<SUB>1</SUB> CONA<SUB>2</SUB>, NHCOA<SUB>1</SUB> NHCONH<SUB>2</SUB>, NHSO<SUB>2</SUB>A, CHO, COA, SO<SUB>2</SUB>NH<SUB>2</SUB> and/or S(O)<SUB>9</SUB>A, A represents an unbranched or branched or cyclic alkyl having 1-14 C-atoms, wherein one or two CH<SUB>2</SUB>-groups can be replaced by O- or S-atoms and/or by CH=CH-groups and/or also, 1-7 H-atoms by F and/or Cl, HaI represents F, CI, Br or I, D represents NH, NH<SUB>2</SUB>, NA<SUB>2</SUB>, NHA<SUB>1</SUB> CH<SUB>2</SUB>, CH<SUB>3</SUB>, OH, OA, O or S, E represents CH<SUB>2</SUB>, CH, NH or N, Y represents E or a saturated or unsaturated connection, X represents CH<SUB>2</SUB>, O or NH, Q represents HaI, A1 OH1 OA, NH<SUB>2</SUB>, NHA, NA<SUB>2</SUB>, NO<SUB>2</SUB>, CN, OCN, SCN, COOH, COOA<SUB>1</SUB> CONH<SUB>2</SUB>, CONHA, CONA<SUB>2</SUB>, NHCOA, NHCONH<SUB>2</SUB>, NHSO<SUB>2</SUB>A, CHO, COA, SO<SUB>2</SUB>NH<SUB>2 </SUB>or X-M. The invention also relates to the production and use thereof for producing a medicament for treating illnesses, in particular tumours and/or illnesses, wherein the development or progression of the kinases are involved. |
| priorityDate | 2005-04-12^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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