http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1888760-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adb0e564374fedf34b36103d36e6455a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-48 |
| filingDate | 2006-06-01^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c9032ef5852f0e2ad1316b20210eb65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ed3ce2ad8eb54e4e9b8c4f59b61b8f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f17b9c7d7bafa9e62de3a62cbf40a73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6231d7b31c90c0a5d1c0d6e8c300fec |
| publicationDate | 2008-02-20^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1888760-A1 |
| titleOfInvention | Biosynthetic production of (5s,6s)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylic acid (2,3-cha) |
| abstract | The invention relates to a process for the biosynthetic production and recovery of [5S,6S]-6-amino-5-hydroxycyclohexa-1 ,3-diene-1-carboxylic acid) catalyzed, at increased enzyme activity, at least by an enzyme belonging to the class of aminodeoxyisochorismate (ADIC) synthases and an enzyme belonging to the class of isochorismatases, wherein (a) the production is carried out fermentatively with a suitable carbon source as starting material in a chorismate overproducing host microorganism, and with an aminodeoxyisochorismate (ADIC) synthase enzyme selected from the group of such ADIC synthase enzymes that are lacking ADIC lyase activity, and (b) the recovery is carried out by means of concentrating the supernatant of the fermentation to a 2,3-CHA concentration of at least 25 g/l, followed by crystallisation from the said concentrated supernatant. In a second embodiment, the present invention relates to the use of [5S,6S]-6-amino-5-hydroxycyclohexa-1 ,3-diene-1-carboxylic acid (2,3-CHA) as a catalytically active product, in particular as a chiral catalyst. Finally, the invention relates to the novel zinc complex of 2,3-CHA. |
| priorityDate | 2005-06-02^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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