| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12R2001-01 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-205 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00 |
| filingDate |
2006-04-19^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-11-30^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddac9d3b5bcaf36b8cf1fc1135819ebe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09845d71cb38c28a98cf49000304573a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b78a961204a39d791f822a034f1b1fb2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c36c2c865b7a925998b4747d5b109b5b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d84a0a9079f441bf2a7465f5055e4320
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff7d7053a70486bf58ca57587301a007
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_244af5ad96cd463be5ffee829e7d03cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56ceb98d749bade8babe242b4b01f069 |
| publicationDate |
2011-11-30^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1893765-B1 |
| titleOfInvention |
A process for preparing (2r,3s)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof |
| abstract |
The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648. |
| priorityDate |
2005-05-25^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |