| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29c5d94f49a24f38a2b3585bfbc3b9d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_753c0e36e3801d4916536a65a77efc35 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
2008-01-11^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe8ded271d1e41debe71e464d582143c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dd7cdef310f5b2bd575935f4fff3fd8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc428af32c8acd8283f8101247f968ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17b35756d5e44785f49e5a3374fa5e18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00a00b4363e21cb191c478578e670aa5 |
| publicationDate |
2009-09-30^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2104682-A2 |
| titleOfInvention |
Diagnosis and treatment of alzheimer's and other neurodementing diseases |
| abstract |
Isolated, monoclonal, human, anti-/3-amyloid antibodies are provided which bind to dimeric forms of Ab with higher affinity than to monomelic forms of Ab and when bound to an Aβ polypeptide comprising Aβ(21 -37) shield Aβ(21-37) from proteolytic digestion. The antibodies were shown to inhibit fibril formation and reduce plaque size in vivo and to not bind brain vessel walls. Accordingly, the antibodies are useful in human and veterinary medicine for the treatment and prophylaxis of Alzheimer's disease and other neurodementing diseases. Methods of detecting or measuring the progression of a neurodementing disease also are provided. |
| priorityDate |
2007-01-11^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |