| abstract |
The present invention is related to study on synthesis of a novel thiophenediamine derivative having a urea structure and finding of a pharmacological action of the derivative. Specifically, the present invention provides a compound represented by formula (1) or a salt thereof. In the formula, R 1 and R 2 may be the same or different and each represents a hydrogen atom, an optionally substituted lower alkyl group or the like; R 3 represents a hydroxy group, an optionally substituted lower alkoxy group, an optionally substituted lower cycloalkyloxy group or the like; R 4 and R 5 may be the same or different and each represents a halogen atom, a lower alkyl group, a hydroxy group or the like; X represents an optionally substituted lower alkylene group or the like; Y represents a single bond, an optionally substituted lower alkylene group or the like; W 1 -W 2 represents N-CH, CH-N or the like; and l and m may be the same or different and each represents 0, 1 or the like. |