http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2414505-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76ba102ea9c02b6633d64bf09c5b89a4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y401-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y604-01001 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y401-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1211 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y604-01001 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-52 |
| filingDate | 2010-04-02^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29a1c5e613c8c0141486dbabbdb5780f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d36810e61bff73022bce8f03bdd030d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b56e9ebd8c5d8fb782e914391ae965b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fa8a572e62a3806b7790cc51496005a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e9f508b848637156f1a4b0db0f5fab6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a2c4b0a74c066913acac90715fd073d |
| publicationDate | 2012-02-08^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2414505-A2 |
| titleOfInvention | Engineering the pathway for succinate production |
| abstract | This invention relates to the biocatalysts for the efficient production of succinic acid and/or other products from renewable biological feedstocks. The biocatalysts have a very high efficiency for the growth-coupled production of succinic acid and/or other products from carbohydrate feed stocks as a result of both genetic manipulations and metabolic evolution. More specifically, certain biocatalysts of the present invention produce succinic acid at high titers and yield in mineral salts media during simple pH-controlled, batch fermentation without the addition of any exogenous genetic material. The genetic manipulations of the present invention are concerned with the energy-conserving strategies coupled with the elimination of alternative routes for NADH oxidation other than the routes for succinic acid production. The biocatalysts contain glucose-repressed gluconeogenic phosphoenol pyruvate carboxykinase (pck) derepressed by genetic modifications and a genetically-inactivated phosphotransferase system. In terms of succinic acid production efficiency, the biocatalysts of the present invention are functionally equivalent to succinate producing rumen bacteria such as Actinobacillus succinogens and Mannheimia succiniproducens with one difference that the biocatalysts are able to achieve this high level of succinic acid production in a minimal salt medium with carbohydrate source as opposed to the requirement for a rich media for succinic acid production by rumen bacteria. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109929862-A |
| priorityDate | 2009-04-02^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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