| abstract |
The present invention provides a pharmaceutical composition for preventing or treating osteoporosis to be administered once a month, the pharmaceutical composition comprising a bisphosphonate derivative, such as risedronic acid (or its salt) or ibandronic acid (or its salt), and cholecalciferol in a high-dose. The present invention also provides a pharmaceutical composition for preventing or treating osteoporosis to be administered once a month, the pharmaceutical composition comprising: (a) cholecalciferol-containing granules obtained by adsorbing on microcrystalline cellulose a solution prepared by dissolving (i) cholecalciferol in an amount corresponding to 24,000 to 50,000 IU; (ii) one or more selected from tocopheryl acetate, butylhydroxytoluene, and butylhydroxyanisol as a first stabilizing agent; and (iii) a binder in ethanol or an aqueous solution of ethanol, (b) mannitol as a second stabilizing agent, and (c) risedronic acid or its salt or ibandronic acid or its salt. |