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filingDate 2008-04-28^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2012-10-31^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2517714-A1
titleOfInvention Recombinant vitamin K dependent proteins with high sialic acid content and methods of preparing same
abstract Methods of isolating highly sialylated recombinant vitamin K dependent proteins, particularly Factor IX, by chromatographic methods are described. The highly sialylated recombinant proteins are characterized. The improved Factor IX has at least 62% N-glycosyslation with 3 or 4 sialic acid residues and improved bioavailability and pharmokinetic properties.
priorityDate 2007-04-26^^<http://www.w3.org/2001/XMLSchema#date>
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