| abstract |
Compositions and methods for the treatment of toxoplasmosis-, caused by the infectious eukaryotic parasite Toxoplasma gondii ( T, gondii ) and for the treatment of ciyptosporidiosis, caused by the infectious eukaryotic parasites Cryptosporidium parvum (C parvuai) and Cnγtosporidium homimus (C . hominus) are described. In particular, the present disclosure is directed to compositions and methods for inhibiting either T. gondii calcium dependent protein kinases ( Tg CDPKs) or C. parvum and C. hominus calcium dependent protein kinases (Cp DPKS) using pyrazolopyriinidine and/or imidazo[l,5- a ]pyraziαe inhibitors, of the formula.(I), wherein the variables X. Y, Z, L. R 1 . and R 3 are defined herein. |