| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4f8755c361b70eb6af66fd6a114e590 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2012-04-13^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a165fd2f1bc010275b1fd3e51d94ab1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e68f7ee1ab6fbd8715e9c43dcd8503f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae108093ab24838d2d831d3769ccc2ef |
| publicationDate |
2014-02-19^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2697393-A1 |
| titleOfInvention |
Process for identifying novel anti-inflammatory molecules with reduced direct transrepression of genes induced by glucocorticoids |
| abstract |
The present invention relates to a new process for identifying novel anti-inflammatory molecules with reduced direct transrepression of genes induced by glucocorticoids. The inventors have discovered that GCs-mediated transrepression can be mediated not only via the tethering indirect pathway, but also through direct binding of GR to "simple" negative GREs (nGRE), which belongs to a novel family of evolutionary-conserved cis-acting negative response elements (IR nGREs), and are found in numerous GC-repressed genes. |
| priorityDate |
2011-04-14^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |