http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2854813-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_11f3d11f8d8648da6793b32160b13ef9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-352 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-336 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-333 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 |
| filingDate | 2013-05-30^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_355ec174dfa750fb64ab2fd7bb9ed9da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac363af3f11bf89363c7436d8689ef5b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d17b4dcde37099541d612a6ee583d533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff3319384cb50d51329ebe2641a6c32a |
| publicationDate | 2015-04-08^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2854813-A1 |
| titleOfInvention | Pyrazolotriazolyl nucleoside analogues and oligonucleotides comprising them |
| abstract | The present invention relates to pyrazolotriazolyl nucleoside analogues, oligonucleotide comprising them, and uses thereof. Further the invention relates to a method for reducing gene expression in a cell comprising transfecting the cell with such an oligonucleotide. It has been found, in accordance with the present invention, that certain pyrazolotriazolyl-based nucleoside analogues such as 8-[3 '-(2-cyanoethyl)-(N,Ndiisopropyl)]-phosphoramidite-(2 '-deoxy-5 '-dimethoxytri ty 1-13-D-ri bofuranozyl )-4-{N-benzoylamino)-pyrazolo [1,5a]-1,3,5-triazine, can be incorporated into oligonucleotides, substituting natural purine nucleosides and imparting acid stability and nuclease stability to the oligonucleotide. Furthermore, oligonucleotides comprising one or more such nucleoside analogues are capable of hybridizing with oligonucleotides having complementary sequences thereto in which no such analogues are incorporated. |
| priorityDate | 2012-05-31^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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