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filingDate 2013-12-19^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e11121251f1cbe6ffb0d0f5a1cc275d
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9fa8b071830a2f37bfa7e190f8d0e4d
publicationDate 2015-10-28^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2934575-A2
titleOfInvention B7-h4 specific antibodies, and compositions and methods of use thereof
abstract B7-H4 specific antibodies and compositions and methods of use thereof are disclosed. The antibodies can be specific for endogenous B7-H4 polypeptides, recombinant B7-H4 proteins and fusions thereof, or combinations thereof. Methods of using B7-H4 specific antibodies to reduce an inflammatory response, or to treat an inflammatory or autoimmune disease/disorders are also disclosed. The antibodies can be administered to a subject to reduce the levels of cell-free B7-H4 in the subject, or reduce cell-free B7-H4 blockage of B7-H4-mediated signal transduction. In some embodiments the antibodies are administered in combination with a B7-H4-Ig fusion protein that mimics transmembrane B7-H4. Preferably, the antibody binds cell-free B7-H4, without binding to the co-administered B7-H4-Ig fusion protein. Methods of diagnosis, determining therapeutic efficacy, and selecting patients for treatment are also disclosed.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017194265-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017149143-A1
priorityDate 2012-12-19^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP12703
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http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID1977
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP08548
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