| abstract |
[Problem] To provide a pharmaceutical composition for treating FGFR4-realted cancer, FGF19-related cancer, or FGF19 gene amplification positive liver cancer. [Solution] The inventors perfected the present invention through study of compounds having FGFR4 inhibitory effect, verifying that specific pyrimidine compounds have FGFR4 inhibitory effect, and that pharmaceutical compositions having these compounds as active ingredients have therapeutic effect against FGFR4-related cancer, or in another mode against FGF19-related cancer, or in yet another mode against FGF19 gene amplification positive liver cancer. |