| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2bcaf91101a370a3d64e3190366357f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2017-05-30^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4c2db1ee8212952ecc6af61009faa5b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a2a9d8ac35b903b59396c6ee952ec79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04ecbc089e7e30c5d942ae6ff0e123b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9f24bdda8ad651503e73c6b2db870ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e729a32af0c7a7afd3baa26fec9e585f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da8af2ea5d76ab984b599bf2b3f4f8fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09728a21084e9cdb779f87b344dfa315 |
| publicationDate |
2018-12-05^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3409785-A1 |
| titleOfInvention |
Continuous spectrometric assay for measuring meprin activity using an auxiliary enzyme |
| abstract |
The present invention relates to assays for measuring meprin activity. More particularly, the assays concern rapid, sensitive, reliable and robust assays for measuring meprin activity comprising a coupled enzyme assay suitable for high-throughput screening. In particular, the invention relates to methods for 1) for assaying meprin catalytic activity; 2) identifying inhibitors of meprin activity; 3) methods for measuring the IC50 of a test compound inhibiting meprin activity; 4) methods for differentiating a competitive inhibitor meprin from a non-competitive inhibitor of meprin; and 5) methods for identifying specific inhibitors for meprin α and meprin β. Further provided is a kit, which can be used to perform the methods of the invention. |
| priorityDate |
2017-05-30^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |