| abstract |
Provided are methods of producing induced pluripotent stem cells, as well as induced pluripotent stem cell comprising an exogenous nucleic acid, or analogue thereof, encoding an ETCHbox protein, or fragment or variant thereof. The methods involve providing a somatic cell with an ETCHbox protein, or fragment or variant thereof, and further providing the cell with a reprogramming factor. The ETCHbox protein may be selected from the group consisting of: ARGFX; TPRX; LEUTX; PARGFX; and DPRX. Also provided are methods of detecting a teratocarcinoma, or its metastases in a subject, and methods of treating teratocarcinoma, or its metastases, in a subject. These methods make use of the ETCHbox protein ARGFX, or the proteins NANOGNB, or HESX1. |