http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3720959-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_de32bf86496942d0974e693eb7e974ba |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1037 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| filingDate | 2018-12-05^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebf7685bbd9c774263d9b21a89dfb864 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eff82a6a66d733ed6acda1d092c9e655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de937279c2d99e229c62518586b5c55a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b49c0d3b050d832146efcdf78d1356f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_befe0706c418169f7b0c389c37ab1b1c |
| publicationDate | 2020-10-14^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3720959-A1 |
| titleOfInvention | Selecting for developability of polypeptide drugs in eukaryotic cell display systems |
| abstract | Use of the surface presentation level of binders (e.g., antibodies, receptors) on cultured higher eukaryotic cells in vitro as a predictive indicator of developability characteristics, e.g., solubility, of the binders. Display libraries of higher eukaryotic cells, e.g., mammalian cells, adapted for use in screening surface-displayed binders for developability and affinity of target binding. High-throughput screening of display libraries with in-built selection for developability including binder solubility, capability to be formulated at high concentrations, low propensity for non-specific binding, and half-life. Enrichment of populations of binders for developability characteristics and/or other qualities such as target binding and affinity, by controlling cell surface presentation of binders from an inducible promoter operably linked to binder-encoding DNA. |
| priorityDate | 2017-12-06^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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