| abstract |
Various neurodegenerative processes are entrained and maintained by signaling through Semaphorin 3A leading to apoptosis and loss of neuronal cells and tissues. Examples of such processes include glaucoma of the eye, stroke, ischemia of the optic nerve and other major nerves, retinal detachment and trauma. Small molecules in solution or in slow release systems are demonstrated to alleviate loss of retinal ganglial cells in models of CNS injury to the eye. |