| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_991894d12fec858eb00e70e8d82344cf |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-89
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M35-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 |
| filingDate |
2019-08-05^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d584e09dfaf69766d64864e0798b3a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1463e60e45fde588495acb45b83ba89d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ae5c7429802b454cac691038ef3e0cd |
| publicationDate |
2021-06-16^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3833768-A1 |
| titleOfInvention |
Systems and methods for aptamer-based intracellular delivery of a payload using nanoneedles |
| abstract |
Methods, chips and systems are provided for the ex vivo delivery of payloads into cells using an aptamer-based approach. Methods are provided for delivering a payload to a cell comprising providing a nanoneedle and a polynucleotide, wherein a first end of the polynucleotide comprises an aptamer capable of binding a molecule endogenous to a cell, wherein the first end of the polynucleotide is conjugated to the nanoneedle, and wherein a second end of the polynucleotide comprises an oligonucleotide capable of hybridizing with a payload; contacting the payload with the polynucleotide, wherein the payload contains a nucleotide sequence that is complementary to the oligonucleotide sequence; and inserting the nanoneedle into a cell, wherein upon insertion of the nanoneedle into the cell the payload is released from the polynucleotide. |
| priorityDate |
2018-08-06^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |