http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3933036-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a30389764e5f0237c45ab39d19256df http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7375f1ede4edbf0e5caf1e599f6397d4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P33-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-06 |
| filingDate | 2020-07-02^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_285e078cdf411e2e1cd5527f36e0cc8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df7f5654f13473cb8a08ee2be315296a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1475f20f1752c037d357a249b19ab270 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2aad27f34f3c20444b5b9fda3d769b1e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c87ec423c35ca4ef0fcc32729a41844 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40ae4a925a946e883b3c1ae701a3e1e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58c95181ab55a26da4668bbffce204f8 |
| publicationDate | 2022-01-05^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3933036-A1 |
| titleOfInvention | Process for 7-beta-hydroxylation of bile acid derivatives |
| abstract | A first aspect of the invention relates to a process for 7-beta-hydroxylation of bile acid derivatives comprising: (a) providing a bile acid derivative according to general formula (I); (b) contacting the bile acid derivative according to general formula (I) with at least one cytochrome P450 monooxygenase analog, wherein the cytochrome P450 monooxygenase analog comprises at least two mutations compared to the parent cytochrome P450 monooxygenase; thereby obtaining a bile acid derivative according to general formula (II) as a product, which has a beta-hydroxyl group in position 7. A second aspect of the invention relates to a bile acid derivative according to general formula (II), which has a beta-hydroxyl group in position 7, obtained or obtainable from the process of the first aspect. In a third aspect, the invention is related to a cytochrome P450 monooxygenase analog, wherein the parent cytochrome P450 monooxygenase of the cytochrome P450 monooxygenase analog is cytochrome P450 monooxygenase CYP107D1 (OleP) from Streptomyces antibioticus according to SEQ ID NO: 1, wherein the cytochrome P450 monooxygenase analog comprises at least two mutations compared to the parent cytochrome P450 monooxygenase at positions selected from the group consisting of 84, 240, and 291. A fourth aspect of the invention is related to a polynucleotide encoding the cytochrome P450 monooxygenase analog of the third aspect. In a fifth aspect, the invention is related to a vector comprising the polynucleotide encoding the cytochrome P450 monooxygenase analog of the third aspect. A sixth aspect of the invention relates to a host cell comprising the cytochrome P450 monooxygenase analog of the third aspect and/or the polynucleotide of the fourth aspect, and/or the vector of the fifth aspect. |
| priorityDate | 2020-07-02^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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