| abstract |
Disclosed are isolated or purified T cell receptors (TCRs) having antigenic specificity for human p53 R175H or human p53 Y220C . Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |