| abstract |
Methods of preventing or treating elevated pulmonary vascular pressure or exercise-induced pulmonary hemorrhage in mammals are provided, the methods comprise administering compositions comprising type V phosphodiesterase inhibitors and an organic base (e.g., meglumine) to the mammal. Compositions, kits and methods of making type V phosphodiesterase inhibitor are also provided. In one embodiment, the composition comprises E-4021, which is sodium 1-[6-chloro-4-(3,4-methylenedioxybenzyl)-aminoquinazolin-2- yl]piperidine-4-carboxylate sesquihydrate and meglumine. |