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publicationDate 2004-04-16^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2204294-A1
titleOfInvention NEW ACTIVE ANTIBIOTICS AGAINST THE ANGUILLARUM VIBRIO AND ITS APPLICATIONS IN CROPS OF FISH, CRUSTACEANS, MOLLUSCS AND OTHER AQUACULTURAL ACTIVITIES.
abstract New active antibiotics against Vibrio anguillarum and its applications in fish, crustaceans, molluscs and other aquaculture activities. 5 diketopiperacins have been found with activity against the bacterium Vibrio anguillarum . These are compounds Z54: cycle (D) -proline- (D) -leucine; Z56: cycle (D) -proline- (D) -Isoucine; Z57: cycle (D) -proline- (D) -valine; Z59: cycle (D) -proline- (D) -phenylalanine and B717: cycle (D) -trans-4-hydroxypropyl- (D) -phenylalanine; obtained from two marine bacteria: Roseobacter gallaecensis . (CECT 5719) and Roseobacter sp. (CECT 5718), isolated from larval cultures of Pecten maximus . The addition of these compounds in a concentration of 0.5 mg / mL to shellfish, crustaceans and fish crops, increases their survival in values ranging from 12% to 33%. Its inhibitory activity is comparable to that of the antibiotics currently used in aquaculture.
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