| abstract |
A compound of ** Formula ** one of its prodrugs or a pharmaceutically acceptable salt of said compound or said prodrug, wherein: A is S, SO or SO2; R1 and R2 are each independently hydrogen or methyl; R3 is Het1, -CHR4Het1 or NR6R7; R4 is hydrogen or (C1-C3) alkyl; R6 is (C1-C6) alkyl, aryl or Het2; R7 is Het3; Het1 is pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, quinolyl, isoquinolyl, quinazolyl, quinoxalyl, phthalazinyl, cinolinyl, naphthyridinyl, pteridinyl, pyrazinopyrazinyl, pyrazinopyridazinyl, pyrimidopyridides substituted for three substituted substituents, substituted substituents of 3 independently from hydroxy, halo, hydroxy (C1-C4) alkyl, (C1-C4) alkoxy-(C1-C4) alkyl, (C1-C4) alkyl optionally substituted with up to five fluoro and C1-C4 alkoxy substituents optionally substituted with up to five fluoro substituents; said imidazolyl, oxazolyl, isoxazolyl, thiazolyl and pyrazolyl in the definition of substituents for Het2 and Het3, are optionally substituted with up to two substituents independently selected from hydroxy, halo, hydroxy-C1-C4 alkyl, alkoxy (C1-C4) - (C1-C4) alkyl, (C1-C4) alkyl optionally substituted with up to five fluoro substituents and (C1-C4) alkoxy optionally substituted with up to three fluoro substituents. |