| abstract |
A compound of formula (See formula) or a pharmaceutically acceptable salt thereof, in which: Z is CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2) n; n is 1-5; R1 is selected from the group consisting of (See formulas) R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; R4 is selected from the group consisting of hydrogen, alkyl, and halogen; R5 is selected from the group consisting of hydrogen, alkoxy, alkyl, halogen, nitro, and -NH2; R6 is selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylthio, alkynyl, aminoalkyl, aminocarbonyl, aminocarbonylalkyl, aminosulfonyl, carboxy, cycloalkyl, carboxy, cycloalkyl, carboxy, alkyl formyl, formylalkyl, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, mercaptoalkyl, nitro, 5-tetrazolyl, -NR7SO2R8, NR10R11, in which R10 and R11 are hydrogen, alkyl, alkylcarbonyl and formyl. -C (NR7) NR7R8, -CH2C (NR7) NR7R8, -C (NOR7) R8, -C (NCN) R7, -C (NNR7R8) R8, -S (O) 2OR7, and -S (O) 2R7; and R7 and R8 are independently selected from the group consisting of hydrogen and alkyl. |