| abstract |
A compound of formula (I) ** see formula ** or a therapeutically acceptable salt thereof, wherein R 1 is selected from the group consisting of alkoxyalkynyl, alkoxycarbonylalkenyl, alkoxycarbonyl-alkyl, alkynyl, aryl, arylalkyl, alkoxy-alkynyl, arylsulfanylalkyl , carboxyalkenyl, carboxyalkyl, carboxyalkynyl, cyanoalkyl, cycloalkylalkynyl, formilalquenilo, halo, heteroaryl, heteroarylalkynyl, heteroarilcarbonilalquenilo, hetero-arylcarbonylalkyl, heterocyclyl, heterocyclyl-alkyl, heterocyclyl alkynyl, heterocyclylcarbonyl-alkenyl, hydroxyalkenyl, hydroxyalkyl, hydroxyalkynyl, NR a R b, (NR a R b) alkenyl, (NR to R b) alkyl, (NR to R b) alkyl, (NR to R b) carbonylalkenyl, (NR to R b) carbonyl alkyl, and nitro; R 2 is selected from the group consisting of hydrogen and alkyl; R 3 is selected from the group consisting of halo, aryl, heteroaryl, and heterocyclyl, where aryl, heteroaryl, and heterocyclyl are optionally substituted with one, two, or three substituents independently selected from the group consisting of alkoxy, alkyl, aryl, cyano, halo, haloalkoxy, haloalkyl, heteroaryl, hydroxyalkyl, LR 4, and NR a R b; provided that at least two of the three substituents are different from LR 4; L is selected from the group consisting of O, NR 5 C (O) (CH2) m, NR 5 SO2, and (CH2) mN (R 5) C (O) N (R 5) (CH2) a, where myn they are 0 1 and where each group is represented with its right end anchored to R 4; R 4 is selected from the group consisting of aryl, arylalkyl, heteroaryl, and heterocyclyl; R 5 and R 6 are hydrogen; R a and R b are independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, cycloalkyl, heterocyclylcarbonyl, (NR to R b) alkylcarbonyl, and R a and R d are independently selected from the group consisting of hydrogen, and alkyl, wherein heteroaryl is selected from benzimidazolyl, benzoxadiazolyl, benzoxazolyl, benzofuranyl, benzisoxazolyl, benzothiazolyl, benzothienyl, cinnolinyl, dibenzofuranyl, furanyl, furyl, imidazolyl, indazolyl, indolyl, isoxazolyl, isoquinolinyl, isothiazolyl, naphthyridinyl, oxadiazolyl, oxadiazolyl, oxazolyl, pyridinyl, pyridazinyl , pyrimidinyl, pyrazinyl, pyrazolyl, pyrrolyl, quinolinyl, thiazolyl, thienopyridinyl, thienyl, triazolyl, thiadiazolyl, and triazinyl, and wherein heterocyclyl is selected from azetidinyl, benzodioxolyl, benzothiazolyl, diazepanyl, dihydroindolyl, dihydroisoindolyl, dihydropyridinyl, 1,3-dioxanyl, 1,4-dioxanyl, 1,3-dioxolanyl, isoindolinyl, mo rfolinyl, piperazinyl, pyrrolidinyl, tetrahydropyridinyl, piperidinyl, and thiomorpholinyl, diazepinyl, imidazolidinyl, morpholinyl. |