http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2362472-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2008-11-25^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-07-06^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68a2e114d6a548353e1109b12463eb87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f4047b40ea35e28a48ea93972f9f462 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1e9078a30d1e5c0ccf05ea611776a71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_638241c54febb2b9cbe7b107c8308709 |
| publicationDate | 2011-07-06^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2362472-T3 |
| titleOfInvention | DERIVATIVES OF 2-BENCILPIRIDAZINONA AS INHIBITORS OF MET-QUINASA. |
| abstract | Compounds of the formula I ** Formula ** R2 is an aromatic heterocycle of 5 or 6 links, saturated or unsaturated or aromatic, with 1 to 4 atoms of N, O and / or S, which can be unsubstituted or mono, bi or trisubstituted by Hal, A, [C (R3) 2] nOR3, N = CR3N (R3) 2, SR3, NO2, CN, COOR3, CON (R3) 2, NR3COA, NR3SO2A, SO2N (R3) 2, S (O ) mA, [C (R3) 2] nN (R3) 2, [C (R3) 2] nHet, O [C (R3) 2] nN (R3) 2, O [C (R3) 2] nHet, S [C (R3) 2] N (R3) 2, S [C (R3) 2] nHet, NR3 [C (R3) 2] nN (R3) 2, NR3 [C (R3) 2] nHet, NHCON (R3 ) 2, NHCONH [C (R3) 2] nN (R3) 2, NHCONH [C (R3) 2] nHet, [C (R3) 2] nNHCO [C (R3) 2] nN (R3) 2, [C (R3) 2] nNHCO [C (R3) 2] n- Het, CON (R3) 2, CONR3 [C (R3) 2] nN (R3) 2, CONR3 [C (R3) 2] nNR3COOA, CONR3 [C (R3) 2] nOR3, CONR3 [C (R3) 2] nHet, COHet, COA and / or = O (oxygen carbonyl), R3 is H or A, R4, R4 'are respectively independent of each other H, Hal, A, OR3, CN, COOR3, CON (R3) 2, NR3COA, NR3SO2A, SO2N (R3) 2 or S (O) mA, Ar is phenyl, naphthyl or unsubstituted or mono, bi or trisubstituted with Hal, A, [ C (R3) 2] nOR3, [C (R3) 2] nN (R3) 2, SR3, NO2, CN, COOR3, CON (R3) 2, NR3COA, NR3SO2A , SO2N (R3) 2, S (O) mA, COHet, Het, O [C (R3) 2] nN (R3) 2, O [C (R3) 2] nHet, NHCOOA, NHCON (R3) 2 , NHCOO [C (R3) 2] nN (R3) 2, NHCOO [C (R3) 2] n- Het, NHCONH [C (R3) 2] nN (R3) 2, NHCONH [C (R3) 2] nHet , OCONH [C (R3) 2] nN (R3) 2, OCONH [C (R3) 2] nHet, CONR3 [C (R3) 2] nN (R3) 2, CONR3 [C (R3) 2] nHet and / or COA Het is a substituted phenyl, naphthyl or biphenyl, a saturated, unsaturated or aromatic bi or trinuclear mono heterocycle with 1 to 4 atoms of N, O and / or S, which can be unsubstituted or mono, bi or trisubstituted by Hal, A, [C (R3) 2] nOR3, [C (R3) 2] nN (R3) 2, SR3, NO2, CN, COOR3 CON (R3) 2, NR3COA, NR3SO2A, SO2N (R3) 2, S (O ) mA, CO-Het1, [C (R3) 2] nHet1, O [C (R3) 2] nN (R3) 2, O [C (R3) 2] nHet1, NHCOOA, NHCON (R3) 2, NHCOO [ C (R3) 2] nN (R3) 2, NHCOO [C (R3) 2] n- Het1, NHCONH [C (R3) 2] nN (R3) 2, NHCONH [C (R3) 2] nHet1, OCONH [ C (R3) 2] nN (R3) 2, OCONH [C (R3) 2] nHet1, CO-Het1, CHO, COA, = S, = NH, = NA and / or = O (carbonyl oxygen), Het1 is a mononuclear heterocycle saturated with 1 to 2 N and / or O atoms, which may be mono- or bis-substituted by A, OA, OH, Hal and / or = O (carbonyl oxygen), A it is unbranched or branched chain alkyl with 1-10 C atoms, where 1-7 H atoms can be replaced by F and / or where one or two non-adjacent CH2 groups can be substituted by O, NH, S, SO, SO2 and / or by groups CH = CH, or cyclic alkyl with 3-7 atoms of C, Hal is F, Cl, Br or I, m is 0, 1 or 2, n is 0, 1, 2, 3 or 4. as well as its pharmaceutical, tautomeric and stereoisomeric salts, including mixtures in all proportions. |
| priorityDate | 2007-12-21^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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