| abstract |
A fusion protein of formula X-Y-Z, wherein: X comprises a portion of the VEGF receptor; And it is a linker moiety; and Z is a multimerization domain, wherein the linker moiety Y is a polypeptide of 5-50 amino acid residues that has an above-average flexibility as determined by the method of predicting flexibility of Karpus and Schultz, 1985, Naturwiss, 72: 212-213, and where said fusion protein binds to VEGF when multimerized. |