| abstract |
CD34-genetically modified stem cells, each of the CD34-genetically modified stem cells containing an exogenous nucleic acid comprising (i) a region encoding a protein that enhances the growth of endothelial cells, a region that is operably linked to (ii) a specific endothelial promoter or promoter / enhancer combination for use in the improvement of microcirculation and / or acute wound healing in a subject who is about to undergo, is undergoing or has undergone surgery or physical trauma in which the introduction of genetically modified CD34 stem cells into the subject's bloodstream is not preceded, accompanied or followed by myeloablation, physical trauma being a birth, or physical trauma being a superficial injury caused by a violent act, and the cells CD34-genetically modified mother are introduced into the bloodstream of the suj This is immediately after the trauma, or the physical trauma being a burn injury, and the genetically modified CD34 stem cells are introduced into the bloodstream of the subject immediately after the physical trauma. |