http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2536191-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d269c8e41f178194d858c230c9f85e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be6c6d7dd1cb8665e82f631c4e11655c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6539 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D275-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D275-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-50 |
| filingDate | 2010-01-06^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-21^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ec491552df306744574ec39f7845e75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1f59188c9a98d2e1c2908175353d26c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b16088c2927fc46270fa9a664d604abb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc4c85105a32aa66200d35038f3c8687 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5164d5ecf09f99f960e8527ab4d3ae4a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81e1d0f5fbc02244b1a361aac5198322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_064d416035bd3ceabbb24388ac4f6226 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57fda495fbfe9da41f609edee0396990 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68b4d47815894d41b69c0239dbeb1912 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3817a854f6f53f0bce09d6a8a102e05c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3bb0edf3954c2c6ef4b156dc1f888e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70d90c95e054dfd3bd05350bf7ff3dd1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_700d6b834e2a0beedf2773e14ca2b79c |
| publicationDate | 2015-05-21^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2536191-T3 |
| titleOfInvention | Sulfonamide derivatives |
| abstract | A compound of formula (I): ** Formula ** in which Z is Het2, optionally substituted on a ring carbon atom with one or more substituents selected from the group consisting of halo, cyano, (C1-C4) alkyl ), halo (C1-C4) alkyl, (C1-C4) alkoxy, halo (C1-C4) alkoxy, (C3-C8) cycloalkyl (C3-C8) cycloalkyl (C1-C4) alkyl, ( C1-C4) -S-, amino, (C1-C4) alkylamino, di-C1-C4 alkylamino, amino (C1-C4) alkyl, (C1-C4) alkylamino-(C1-C4) alkyl and di [(C1-C4) alkyl] amino (C1-C4) alkyl; and / or Het2 is optionally substituted on a ring nitrogen atom with (C1-C4) alkyl, halo (C1-C4) alkyl and (C3-C8) cycloalkyl; with the proviso that Z is not tetrazolyl; Y1, Y2, Y3 and Y4 are each independently CH, CR1 or N, with the proviso that no more than two of Y1, Y2, Y3 and Y4 are N; each R1 is independently selected from the group consisting of halo, cyano, amino, hydroxy, (C1-C4) alkyl, halo (C1-C4) alkyl, hydroxy (C1-C4) alkyl, (C1-C4) alkoxy , halo (C1-C4) alkoxy, (C1-C4) alkoxy-(C1-C4) alkyl, - C (O) H, -C (O) -alkyl (C1-C4) and -C (O) N (R2) 2; each R2 is independently hydrogen, (C1-C4) alkyl, halo (C1-C4) alkyl, hydroxy (C1-C4) alkyl or (C3-C6) cycloalkyl; or, when a nitrogen is substituted with two R2 groups, each independently selected from (C1-C4) alkyl, halo (C1-C4) alkyl or hydroxy (C1-C4) alkyl, they can be taken together with the N atom to which they are attached to form a 4- to 6-membered ring which, when formed in this way, can therefore be optionally substituted with hydrogen, alkyl, halo, hydroxy, hydroxyalkyl or haloalkyl; B is phenyl or Het2, in which, when B is Het2 it is attached to the oxy linker in a carbon atom of the ring and where B is also optionally substituted in a carbon atom of the ring with one or more substituents selected from the group that consists of halo, cyano, hydroxy, (C1-C4) alkyl, halo (C1-C4) alkyl, (C1-C4) alkoxy, halo (C1-C4) alkoxy, cyano-(C1-C4) alkyl, amino , (C1-C4) alkylamino, di-C1-C4 alkylamino, amino (C1-C4) alkyl, (C1-C4) alkylamino (C1-C4) alkyl, di [(C1-C4) alkyl] amino - (C1-C4) alkyl, trifluoromethylthio, hydroxy (C1-C4) alkyl, (C1-C4) alkoxy-(C1-C4) alkyl, -C (O) R2, -C (O) OR2, -OC ( O) R2, -C (O) -N (R2) 2, -CH2-C (O) R2, -CH2-C (O) OR2, -CH2- OC (O) R2, -CH2-C (O) -N (R2) 2, S (O) 2R2, S (O) 2N (R2) 2, cycloalkyl (C3-C8) and cycloalkyl (C3-C8) -alkyl (C1-C4); and / or Het2 is optionally substituted on a ring nitrogen atom with a substituent selected from the group consisting of (C1-C4) alkyl, halo (C1-C4) alkyl, hydroxy (C1-C4) alkyl, alkoxy (C1-C4) - (C1-C4) alkyl, amino (C1-C4) alkyl, (C1-C4) alkylamino-(C1-C4) alkyl, di [(C1-C4) alkyl] (C1-amino) alkyl -C4), -CH2-C (O) R2, -CH2- C (O) OR2, -CH2-C (O) -N (R2) 2, S (O) 2R2 and S (O) 2N (R2) two; X is absent, -O-, methylene, ethylene, methylene-O- or -O-methylene; C is cycloalkyl (C3-C8), Het1, phenyl or Het2, each optionally substituted on a ring carbon atom with one or more substituents selected from the group consisting of halo, cyano, hydroxy, (C1-C4) alkyl , halo (C1-C4) alkyl, (C1-C4) alkoxy, halo (C1-C4) alkoxy, N (R2) 2, (R2) 2N-(C1-C4) alkyl, trifluoromethylthio, hydroxy-C1 (alkyl) - C4), (C1-C4) alkoxy-(C1-C4) alkyl, -C (O) R2, -C (O) OR2, -OC (O) R2, -C (O) -N (R2) 2 , -CH2-C (O) R2, -CH2-C (O) OR2, -CH2- OC (O) R2, -CH2-C (O) -N (R2) 2, S (O) 2R2, S ( O) 2N (R2) 2, cycloalkyl (C3-C8) -alkyl (C1-C4), cycloalkoxy (C3-C8), cycloalkylamino (C3-C8), cycloalkylamino (C3-C8) -alkyl (C1-C4), cycloalkyl (C3-C8) -alkylamino (C1-C4), cycloalkyl (C3-C8) -alkylamino (C1-C4) -alkyl (C1-C4), cycloalkyl (C3-C8) -alkoxy (C1-C4) and D ; and / or Het2 is optionally substituted on a ring nitrogen atom with a substituent selected from the group consisting of hydroxy, (C1-C4) alkyl, halo (C1-C4) alkyl, amino (C1-C4) alkyl , (C1-C4) alkylamino-(C1-C4) alkyl, di [(C1-C4) alkyl] amino (C1-C4) alkyl, hydroxy (C1-C4) alkyl, (C1-C4) alkoxy (C1-C4), -C (O) R2, - C (O) OR2, -CH2-C (O) R2, -CH2-C (O) OR2, -CH2-C (O) -N (R2) 2, S (O) 2R2 and S (O) 2N (R2) 2 and D; D is phenyl, benzyl, (C3-C8) cycloalkyl or Het1, each optionally substituted on a carbon atom with one or more substituents independently selected from the group consisting of halo, cyano, hydroxy, (C1-C4) alkyl, halo (C1-C4) alkyl, (C1-C4) alkoxy, halo (C1-C4) alkoxy, amino, (C1-C4) alkylamino, di-C1-C4 alkylamino, amino (C1-C4) alkyl ), (C1-C4) alkylamino-(C1-C4) alkyl, di [(C1-C4) alkyl] amino (C1-C4) alkyl, trifluoromethylthio, hydroxy (C1-C4) alkyl, (C1-C4) alkoxy ) -C1-C4 alkyl, -C (O) R2, -C (O) OR2, -OC (O) R2, -C (O) -N (R2) 2, -CH2-C (O) R2 , - CH2-C (O) OR2, -CH2-OC (O) R2, -CH2-C (O) -N (R2) 2, S (O) 2R2 and S (O) 2N (R2) 2. |
| priorityDate | 2009-01-12^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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