http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2537128-T3

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filingDate 2010-08-13^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-06-02^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c135db8b1c8fa68182fe162365d1adf
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publicationDate 2015-06-02^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2537128-T3
titleOfInvention Pharmaceutical composition to suppress pain
abstract Pharmaceutical composition for use in the relief of pain in a human joint disease, comprising: a hyaluronic acid that is crosslinked by cyclization of a double bond in a residue of a cinnamic acid in a partially amidated hyaluronic acid represented by the formula (1 ), to form a cyclobutane ring, [Ar-CH> = CH-COO- (CH2) n-NH-] m-HA (1) in which Ar represents an optionally substituted phenyl group, n represents an integer number of 2 or 3, HA represents a carboxyl residue of hyaluronic acid, and m represents the ratio of amidation of hyaluronic acid with respect to the total carboxyl group and is from 3% to 50% in relation to the total carboxyl group; and a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is a product for injection, in which an individual dosage of the product for injection is 2 to 3 ml; and wherein the pharmaceutical composition is an individual dose preparation, and is administered in an administration range of 13 weeks or more.
priorityDate 2009-08-13^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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