| abstract |
Ethynyl derivatives of the formula I ** Formula ** in which: U is> = N- or> = C (R5) -; V is -CH> = or -N> =; W is> = CH- or> = N-; with the proviso that only one of U, V or W can be nitrogen, R5 is hydrogen, methyl or halogen; Y is -N (R6) -, -O-, -C (R7 ') (R7) -, -CH2O- or -CH2S (O) 2-; said R6 is hydrogen or C1-4 alkyl and R7 / R7 'independently of one another are hydrogen, hydroxy, C1-4 alkyl or C1-4 alkoxy; R1 is phenyl or heteroaryl, which are optionally substituted by one or two substituents chosen from halogen, C1-4 alkyl and C1-4 alkoxy; R2 / R2 'independently of each other are hydrogen, C1-4 alkyl, hydroxy, C1-4 alkoxy, C3-C6 cycloalkyl, CH2-C1-4 alkoxy or together with the carbon atom to which they are attached can form a C3 cycloalkyl -C6 or a ring containing - CH2OCH2-; m is the number 0, 1 or 2; in the case where m is 1, R3 / R3 'independently of one another are hydrogen, C1-4 alkyl, CH2-C1-4 alkoxy or together with the carbon atom to which they are attached can form a C3-C6 cycloalkyl; or R3 and R2 together with the carbon atom to which they are attached can form a C3-6 cycloalkyl or a ring containing - (CH2) 2OCH2-; n is the number 0 or 1; in the case where n is 1, R4 / R4 'independently of one another are hydrogen, C1-4 alkyl, CH2-C1-4 alkoxy or together with the carbon atom to which they are attached can form a C3-C6 cycloalkyl; R4 and R2 together with the carbon atom to which they are attached can form a C3-6 cycloalkyl; or if n is 0 and Y is -N (R6) -, then R6 and R2 together with the carbon atom and the nitrogen atom to which they are attached can form a C3-6 cycloalkyl; or if n and m are 0, then R2 and R7 together with the carbon atoms to which they are attached can form a C3-6 cycloalkyl; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomers and / or optical isomers and / or stereoisomers. |