http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2572908-T3

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filingDate 2012-10-12^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2016-06-03^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f14706fa730a7d207793842f3906bdf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a28e4230fa1667a4b6c44fb85af3f8aa
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publicationDate 2016-06-03^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2572908-T3
titleOfInvention Tetrahydroisoquinoline compounds substituted as factor XIa inhibitors
abstract A compound according to Formula (I): ** Formula ** or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein: ring A is C3-10 carbocycle; L is selected from the group consisting of: a link, -CHR10CHR10-, -CR10> = CR10- and -C≡C-; Q is selected from the group consisting of: C, CH and N; --- it is an optional link; provided that when Q is N, the optional link is absent; Ring B is a 5-6 membered heterocycle containing carbon atoms and 1-3 heteroatoms selected from the group consisting of N, NR6, O and S (O) p, wherein said heterocycle is substituted with 0-3 R5; optionally, ring B is further condensed with a phenyl ring substituted with 0-2 R5 or a 5- to 6-membered heteroaryl containing carbon atoms and 1-2 heteroatoms selected from the group consisting of N, NR6, O and S (O) p; wherein said heteroaryl is substituted with 0-2 R5; R1, in each case, is selected from the group consisting of: H, halo, C1-2 alkyl, -O (C1-4 alkyl), CN, -CH2NH2 and -C (> = NH) NH2; R2 is selected from the group consisting of: H, halo, CN, OH, C1-6 alkyl, C1-4 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, CO (C1-4 alkyl), CONH2, CO2H and a 5- to 7-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NH, N (C1-4 alkyl), O and S (O) p, wherein said heterocycle is substituted with 1-2 R2a ; R2a, in each case, is selected from the group consisting of: H, halo, C1-4 alkyl, CO2H, -CO2 (C1-4 alkyl), -CONH2, -CH2OH, -CH2O C1-4 alkyl and -CH2NH2 ; R3 is selected from the group consisting of: C1-6 alkyl substituted with 1-3 R3a, C3-10 carbocycle substituted with 1-3 R3a and 5-10 membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of N, NR7, O and S (O) p; wherein said heterocycle is substituted with 1-3 R3a; R3a, in each case, is selected from the group consisting of: H,> = O, halo, C1-4 alkyl, -OH, C1-4 alkoxy, -CN, -NH2, -NH (C1-4 alkyl) , -N (C1-4 alkyl) 2, -CO2H, -CH2CO2H, -CO2 (C1-4 alkyl), -CO2-C1-4 alkylene-O (C1-4 alkyl), -CO2-C1-4 alkylene- N (C1-4 alkyl) 2, -CO2-C1-4 alkylene-C1-4 alkylene-C1 (C1-4 alkyl) 2, -CO2- C1-4 alkylene-C1-4-alkylene ( C1-4 alkyl), -CONH2, -CONH (C1-6 alkyl), -CON (C1-4 alkyl) 2, -CONH- C1-4 alkylene-CO2 (C1-4 alkyl), -CONHCO2 C1-4 alkyl, -CONH-C1-4 alkylene-NHCO (C1-4 alkyl), -CONH- C1-4 alkylene-CONH2, -NHCO C1-4 alkyl, -NHCO2 (C1-4 alkyl), -CH2NHCO2 (C1-4 alkyl) , Rc, -CONHRc and -CO2Rc; R4, in each case, is selected from the group consisting of: H, halo and C1-4 alkyl; R5 is selected from the group consisting of: H, halo, C1-4 alkyl substituted with 0-2 Rb, C2-4 alkenyl substituted with 0-2 Rb, C2-4 alkynyl substituted with 0-2 Rb, -OH, -CN, NO2, -NH2, -N (C1-4 alkyl) 2, -O (C1-4 alkyl), - OCO (C1-4 alkyl), -O-C1-4 alkylene-C1 (C1-4 alkyl ), -O-C1-4-N alkylene (C1-4 alkyl) 2, -CO2H, -CO2 (C1-4 alkyl), - CONH2, - (CH2) 2CONH2, -CONR9 (C1-4 alkyl), - CON (C1-4 alkyl) 2, -CONR9-C1-4 alkylene-O (C1-4 alkyl), - CONR9-C1-4 alkylene (C1-4 alkyl) 2, -CONR9-C1-4 alkylene- CO2 (C1-4 alkyl), -NR9CO C1-4 alkyl, - NR9CO2 C1-4 alkyl, -NR9CONH (C1-4 alkyl), -NR9CONR9-C1-4 alkylene-CO2 C1-4 alkyl, -NR9-C1-4 alkylene- N (C1-4 alkyl) 2, -NR9SO2 (C1-4 alkyl), -SO2NH2, R8, -OR8, -COR8, -CO2R8, -CONR9R8, -NR9COR8, -NR9CO2R8 and -NR9CONR9R8; R6 is independently selected in each case from the group consisting of: H, C1-4 alkyl, CO C1-4 alkyl, CO2 C1-4 alkyl, CO2Bn, -CONH-C1-4 alkylene-C1-4 alkyl, phenyl and benzyl; R7, in each case, is selected from the group consisting of: H, C1-4 alkyl, CO C1-4 alkyl, CO2 (C1-4 alkyl), CO2Bn, -CONH-C1-4 alkylene-CO2 C1- alkyl 4, phenyl, benzyl and -CO2-C1-4-aryl alkylene; R8 is independently selected in each case from the group consisting of: - (CH2) C3-10 n-carbocycle and - (CH2) 5 to 10 membered n-heterocycle containing selected carbon atoms and 1-4 heteroatoms between the group consisting of N, NRa, O and S (O) p; wherein said carbocycle or heterocycle is substituted with 0-3 Rb; R9 is selected, independently in each case, from the group consisting of: H and C1-4 alkyl;
priorityDate 2011-10-14^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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