http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2576128-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8073450a491d200d05b09b9beb6f0ec6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8381805eba6d034fc77bd230dd02e6e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1082 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate | 2013-12-12^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-07-05^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d41065ba336f7d0d1979b242ec41f824 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_880e9dd03888ce5bc6daf7fb1d5942cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ac002cfd1ae4996b368ebd82ec6669c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c6b4afdf5e1f9b286f9ccb68bfb5ccf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ed9444384e50d9d58f8a22e1ca5ac2b |
| publicationDate | 2016-07-05^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2576128-T3 |
| titleOfInvention | Modification by genetic technology and optimization of systems, methods and compositions for the manipulation of sequences with functional domains |
| abstract | A composition that is produced unnaturally or that is produced by genetic engineering, comprising: a supply system operatively configured to deliver components of a CRISPR-Cas complex or polynucleotide sequences comprising or encoding said components in a eukaryotic cell, wherein said CRISPR-Cas complex is operative in the eukaryotic cell; I. one or more CRISPR-Cas complex polynucleotide sequences that comprise or encode expression in the eukaryotic cell: (a) a guide sequence capable of hybridizing to a target sequence in a eukaryotic cell, (b) a tracr pairing sequence , and (c) a tracr sequence, and II. a CRISPR enzyme comprising one or more heterologous functional domains or a polynucleotide encoding a CRISPR enzyme comprising one or more heterologous functional domains for expression in the eukaryotic cell; wherein the tracr pairing sequence hybridizes to the tracr sequence, the guiding sequence directs the specific binding for the sequence of a CRISPR complex to the target sequence, the CRISPR complex comprises the CRISPR enzyme complexing with (1) the guide sequence that hybridizes to the target sequence, and (2) the tracr pairing sequence that hybridizes with the tracr sequence, the CRISPR enzyme comprises one or more mutations, so that the enzyme has altered nuclease activity compared to the wild type enzyme, wherein the one or more heterologous functional domains comprises one or more NLS Nuclear Location Signals (s). |
| priorityDate | 2012-12-12^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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