| abstract |
A compound of formula I: ** Formula ** wherein Z is a pyrazole, selected from: ** Formula ** Ar, is selected from ** Formula ** R1, is selected from -SO2NHC ( O) R1a, tetrazolyl, -C (O) OR1b, ** Formula ** wherein, R1a, is -C1-6alkyl, -C0-6alkylene-OR, -C3-7cycloalkyl, -C0-5alkylene NR1bR1c, pyridyl, isoxazolyl, methylisoxazolyl, pyrrolidinyl, morpholinyl, and phenyl optionally substituted by halo; wherein each R1b is independently selected from H and -C1-6alkyl; a, is 0, 1, or 2; R 2 is F; R3 is selected from -C2-5alkyl and -O- C1-5alkyl; R4 is selected from -CH2-SR4, -CH2-N (OH) C (O) H, -CH (R4b) C (O) NH (OR4d), and -CH (R4b) C (O) OR4c; wherein R4a is H or -C (O) -C1-6alkyl; R4b is H or -OH; R4c is H, -C1-6alkyl, -C0-6alkylene-morpholine, -CH2OC (O) O1-6alkyl, -CH (CH3) OC (O) O- C1-6alkyl, -CH (CH3) OC (O) O- C3-7 cycloalkyl, or: ** Formula ** R4d, is H or -C (O) -R4e; and R4e, is -C 1-6 alkyl, -C 1-6 alkyl-NH2 or aryl; and R5 is selected from -C1-6alkyl, -CH2-furanyl, -CH2-thiophenyl, benzyl, and benzyl, substituted by one or more halo, or -CH3, or -CF3 groups; wherein each ring, in Ar, is optionally substituted by 1 to 3 substituents, independently selected from -OH, - C1-6alkyl, -C2-4alkenyl, -C2-4alkynyl, - CN, halo, -O-C1-6alkyl, -C1-6alkyl, -S (O) - C1-6alkyl, -S (O) 2- C1-4alkyl, -phenyl, -NO2, -NH2, -NH-C1-6alkyl and -N (C1-6alkyl) 2, wherein each alkyl, alkenyl and alkynyl is optionally substituted by 1 to 5 fluorine atoms; or a pharmaceutically acceptable salt thereof. |