http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2645689-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c9e4cedb72851f01dadac14d585e8b17 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65586 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-657172 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65583 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6512 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65846 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-650905 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6521 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65218 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 |
| filingDate | 2009-05-21^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-07^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_028e9e67807f75471b471b22d31517dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21c728604adbe5b59c8a20e8a9f7ccdd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4201eab0112a6e43c872509ca52b5e62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63bd81ce977ddbde422054e8b6440ed2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ab64905a27d231e7d8d39e865c44ef6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4e74164e8d9bf5941325d40340afb94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecf372301e7c3cb817b584ed7ae44eac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbf0bc2c764322c506e99d14b9bc508c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b64f3b3c2ec9fc508659131de2d2c66c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24d27bbe1a4508889636249997b86517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7f410d253d778c52d4d85055d7a6584 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee0546deb97f62f60c9533c188097113 |
| publicationDate | 2017-12-07^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2645689-T3 |
| titleOfInvention | Phosphorus derivatives as kinase inhibitors |
| abstract | A compound of formula VIa: ** Formula ** in which X1 is N; X3 is CRd; X4 is CRe; Ring A and Ring E are each phenyl rings; each case of Ra, Rb, Rd, Re, and Rg is independently selected from the group consisting of halogen, -CN, -NO2, -R1, -OR2, -O-NR1R2, -NR1R2, -NR1-NR1R2, -NR1 -OR2, -C (O) YR2, -OC (O) YR2, -NR1C (O) YR2, -SC (O) YR2, - NR1C (> = S) YR2, -OC (> = S) YR2, - C (> = S) YR2, -YC (> = NR1) YR2, -YC (> = N-OR1) YR2, -YC (> = N-NR1R2) YR2, -YP (> = O) (YR3) ( YR3), -Si (R3a) 3, -NR1SO2R2, -S (O) rR2, -SO2NR1R2 and -NR1SO2NR1R2; or, alternatively, each Ra and Rg can also be an independently selected moiety, -P (> = O) (R3) 2 or a ring system containing the moiety -P (> = O) (R3) - as ring member; or, alternatively, two adjacent Ra residues may form, with the atoms to which they are attached, a condensed, 5, 6 or 7-membered ring, saturated, partially saturated or unsaturated, containing 0-4 heteroatoms selected from N , O and S (O) ry which can accommodate up to four substituents; at least one of Ra and Rg is or contains a remainder -P (> = O) (R3) 2 or a ring system containing the remainder -P (> = O) (R3) - as a member of the ring; at least one Ra is selected from: ** Formula ** Ring A optionally contains up to two additional Ra residues; Ring E contains an Rg moiety that is a -P (> = O) (R3) 2 moiety in ortho, meta or para, and optionally contains up to two additional Rg moieties; L is NH; r is 0, 1 or 2; s is 1, 2, or 3; p is 1, 2, or 3; each case of Y is independently a bond, -O-, -S- or -NR1-; each case of R1 and R2 is independently H or an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroalkyl, heterocyclic or heteroaryl moiety; each case of R3 is independently an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroalkyl, heterocyclic or heteroaryl moiety, or two adjacent R3 moieties combine to form a ring system that includes a phosphorus atom; each case of R3a is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroalkyl, heterocyclic, and heteroaryl; alternatively, each NR1R2 moiety may be a saturated, partially saturated or unsaturated 5, 6 or 7-membered ring, which may be optionally substituted and containing 0-2 additional heteroatoms selected from N, O and S (O) r; and the alkyl groups have 1 to 8 carbon atoms; alkenyl groups have 2 to 8 carbon atoms; alkynyl groups have 2 to 8 carbon atoms; cycloalkyl groups have 3 to 13 carbon atoms; cycloalkenyl groups have 3 to 13 carbon atoms; cycloalkynyl groups have 5 to 13 carbon atoms; the heteroalkyl groups are an alkyl, alkenyl, or branched or unbranched alkynyl group having 1 to 7 carbon atoms in addition to 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, O, S, and P ; aryl groups are groups of aromatic rings having 6 to 14 atoms in the ring; heteroaryl groups are heterocyclic aromatic moieties having 5-14 ring atoms comprising one or more rings; the heterocyclic groups are non-aromatic ring systems having 5 to 14 ring atoms in 1, 2 or 3 rings, in which 1 to 4 ring carbons are each substituted by a heteroatom selected from N, O, or S ; each of the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, heteroalkyl, aryl, heteroaryl, and non-aromatic heterocyclic moieties is optionally substituted; Optional substituents on the unsaturated carbon atom of an aryl or heteroaryl group are selected from halogen (F, Cl, Br or I), alkyl, alkenyl, alkynyl, heteroalkyl, -CN, -R1, -OR2, -S (O ) rR2 (where r is an integer of 0, 1 or 2), -SO2NR1R2, -NR1R2, -O-NR1R2, -NR1-NR1R2, - (CO) YR2, -O (CO) YR2, -NR1 (CO) YR2, -S (CO) YR2, - NR1C (> = S) YR2, -OC (> = S) YR2, -C (> = S) YR2, -YC (> = NR1) YR2, -YC (> = N-OR1) YR2, -YC (> = N-NR1R2) YR2, -COCOR2, - COMCOR2 (where M is an alkyl group of 1-6 carbons), -YP (> = O) (YR3 ) (YR3), -Si (R3a) 3, -NO2, -NR1SO2R2 and - NR1SO2NR1R2; Optional substituents in the alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, cycloalkynyl or non-aromatic heterocyclic group are selected from halogen (F, Cl, Br or I), alkyl, alkenyl, alkynyl, heteroalkyl, -CN, -R1 , -OR2, -S (O) rR2 (where r is an integer of 0, 1 or 2), -SO2NR1R2, -NR1R2, -O-NR1R2, -NR1-NR1R2, - (CO) YR2, - O (CO) YR2, -NR1 (CO) YR2, -S (CO) YR2, -NR1C (> = S) YR2, -OC (> = S) YR2, -C (> = S) YR2, - YC ( > = NR1) YR2, -YC (> = N-OR1) YR2, -YC (> = N-NR1R2) YR2, -COCOR2, -COMCOR2 (where M is an alkyl group of 1-6 carbons), - YP (> = O) (YR3) (YR3), -Si (R3a) 3, -NO2, -NR1SO2R2 and -NR1SO2NR1R2; and (in a saturated carbon atom)> = O,> = S,> = NH,> = NNR2R3,> = NNHC (O) R2,> = NNHCO2R2, or> = NNHSO2R2, in which R2 and R3 in each If they are independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, heteroalkyl, aryl, heteroaryl and heterocyclyl; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2008-05-21^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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