| abstract |
A compound of formula: ** Formula ** in which: V is alkyl; L is benzimidazolyl; M is a 5-membered heteroaryl ring; A15 is: ** Formula ** each H14 is independently an unsaturated, partially unsaturated or saturated condensed tricyclic carbocycle that is optionally substituted with one or more groups independently selected from RA1 and RA3; and each XA is independently O, NR, SO, SO2, C (> = O), NRC (> = O), C (> = O) NR, CR> = CR, NRC (> = O) NR, alenyl, alkynyl or absent; each R is independently selected from H or alkyl; each RA1 is independently selected from cyano, nitro, SOR4, SO2R4, -alkylSO2R4, haloalkoxy, cyanoalkyl, NR4SO2R4, cycloalkyl, (halo) cycloalkyl, heterocycle, (cycloalkyl) alkyl, (heterocycle) alkyl, wherein each alkyl, heterocycle and cycloalkyl is optionally substituted with one or more halos; each RA3 is independently selected from alkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, arylalkoxycarbonyl, carboxy, formyl, halo, haloalkyl, hydroxy, hydroxyalkyl, -NRaRb, (NRaRb) alkyl and (NRaRb) carbonyl; Ra and Rb are each independently selected from the group consisting of hydrogen, alkenyl, alkyl, alkylcarbonyl, aryl, arylalkyl, arylalkylcarbonyl, cycloalkyl, cycloalkylalkyl, heterocyclyl and heterocyclylalkyl; each R4 is independently selected from H, alkyl, haloalkyl, aryl and arylalkyl; and each P is independently selected from: ** Formula ** or a pharmaceutically acceptable salt thereof. |