http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2647317-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b50cf1f3833b0668717e87891112651a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-423 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-423 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2009-11-03^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-20^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ade4ec4111e0580a1be461f1a117990 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c001cf0e7367c5b064c2d1a811398be8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb5b840a29af6715b812bd4004e20d0c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f847d7196470f2fd62600e7e35792d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c1b3b2ea35db4145877cf1f4188999d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_126931e970200b80f1b96888afe0f727 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68e7eff1f96b1d8974042c70afbca408 |
| publicationDate | 2017-12-20^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2647317-T3 |
| titleOfInvention | Analogs of CC-1065 and its conjugates |
| abstract | A compound of formulas (I) or (II): ** Formula ** or a pharmaceutically acceptable salt, hydrate or solvate thereof, wherein DB is a DNA-binding moiety and is ** Formula ** R1 is a halide (fluoride, chloride, bromide and iodide), azide, a sulfonate (for example, an optionally substituted C1-6 alkanesulfonate, such as methanesulfonate and trifluoromethanesulfonate, or an optionally substituted C7-12 alkylbenzenesulfonate, such as p-toluenesulfonate) , Succinimide N-oxide, p-nitrophenoxide, pentafluorophenoxide, tetrafluorophenoxide, a carboxylate and aminocarboxylate (carbamate) or an alkoxycarboxylate (carbonate); R2, R2 ', R3, R3', R4, R4 ', R12 and R19 are independently selected from H, OH, SH, NH2, N3, NO2, NO, CF3, CN, C (O) NH2, C (O) H, C (O) OH, halogen, Ra, SRa, S (O) Ra, S (O) 2Ra, S (O) ORa, S (O) 2ORa, OS (O) Ra, OS (O) 2Ra, OS (O) ORa, OS (O) 2ORa, ORa, NHRa, N (Ra) Rb, + N (Ra) (Rb) Rc, P (O) (ORa) (ORb), OP (O) (ORa) (ORb), SiRaRbRc, C (O) Ra, C (O) ORa, C (O) N (Ra) Rb, OC (O) Ra, OC (O) ORa, OC (O) N (Ra) Rb, N (Ra) C (O) Rb, N (Ra) C (O) ORb and N (Ra) C (O) N (Rb) Rc, where Ra, Rb and Rc are independently selected from H and C1 alkyl -3 or optionally substituted C1-3 heteroalkyl, or R3 + R3 'and / or R4 + R4' are independently selected from> = O,> = S,> = NOR18,> = C (R18) R18 'and> = NR18 , R18 and R18 'being independently selected from H and optionally substituted C1-3 alkyl, two or more of R2, R2', R3, R3 ', R4, R4' and R12 being optionally linked by one or more bonds to form one or more optionally substituted carbocycles and / or heterocycles; X2 is selected from O, C (R14) (R14 ') and NR14', where R14 and R14 'have the same meaning as defined for R7 and are independently selected, or R14' and R7 'are absent, giving resulting in a double bond between the atoms designated to carry R7 'and R14'; R5, R5 ', R6, R6', R7 and R7 'are independently selected from H, OH, SH, NH2, N3, NO2, NO, CF3, CN, C (O) NH2, C (O) H, C ( O) OH, halogen, Re, SRe, S (O) Re, S (O) 2Re, S (O) ORe, S (O) 2ORe, OS (O) Re, OS (O) 2Re, OS (O) ORe, OS (O) 2ORe, ORe, NHRe, N (Re) Rf, + N (Re) (Rf) Rg, P (O) (ORe) (ORf), OP (O) (ORe) (ORf), SiReRfRg, C (O) Re, C (O) ORe, C (O) N (Re) Rf, OC (O) Re, OC (O) ORe, OC (O) N (Re) Rf, N (Re) C (O) Rf, N (Re) C (O) ORf and N (Re) C (O) N (Rf) Rg, where Re, Rf and Rg are independently selected from H and (CH2CH2O) eeCH2CH2X13Re1, alkyl C1-15, C1-15 heteroalkyl, C3-15 cycloalkyl, C1-15 heterocycloalkyl, C5-15 aryl or C1-15 heteroaryl optionally substituted where ee is selected from 1 to 1000, X13 is selected from O, S and NRf1 , and Rf1 and Re1 are independently selected from H and C1-3 alkyl, two or more of Re, Rf and Rg being optionally linked by one or more bonds to form one or more optionally substituted carbocycles and / or heterocycles, or R5 + R5 'and / or R6 + R6' and / or R7 + R7 'was selected are independently between> = O,> = S,> = NORe3,> = C (Re3) Re4 and> = NRe3, with Re3 and Re4 being independently selected from H and optionally substituted C1-3 alkyl, or R5 '+ R6' and / or R6 '+ R7' and / or R7 '+ R14' are absent, resulting in a double bond between the atoms designated to carry R5 'and R6', and / or R6 'and R7', and / or R7 'and R14 ', respectively, two or more of R5, R5', R6, R6 ', R7, R7', R14 and R14 'being optionally linked by one or more bonds to form one or more optionally substituted carbocycles and / or heterocycles; X1 is selected from O, S and NR13, wherein R13 is selected from H and optionally substituted C1-8 alkyl or C1-8 heteroalkyl and is not attached to any other substituent; X3 is selected from O, S, C (R15) R15 ', -C (R15) (R15') - C (R15 ") (R15" ') -, -N (R15) -N (R15') -, -C (R15) (R15 ') - N (R15 "') -, - N (R15") - C (R15) (R15 ') -, -C (R15) (R15') - O-, -OC (R15) (R15 ') -, -C (R15) (R15') - S-, -SC (R15) (R15 ') -, -C (R15)> = C (R15') -,> = C (R15) -C (R15 ')> =, -N> = C (R15') -,> = NC (R15 ')> =, -C (R15)> = N-,> = C (R15) - N> =, -N> = N-,> = NN> =, CR15, N and NR15; X4 is selected from O, S, C (R16) R16 ', NR16, N and CR16; |
| priorityDate | 2008-11-03^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Showing number of triples: 1 to 640 of 640.