http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2665675-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7c5e77c181522ee1fd44df1ae5ac2196 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 |
| filingDate | 2014-08-07^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-26^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edca6f35678fb622d87cbe2a62f67c60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4058bdd707df8afe33960c86dd409e37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31c32c3431b639391b2965e5b8638793 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ebe402ba6711a8f6dc8f66bda56ae7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08937675b7a6d15767de25bedc93563d |
| publicationDate | 2018-04-26^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2665675-T3 |
| titleOfInvention | Piperidine and azepine derivatives as procineticin receptor modulators |
| abstract | A compound of formula ** (See formula) ** where: R1 represents a C5-C10 aryl group that is optionally substituted by at least one substituent independently selected from halogen, hydroxyl, cyano, oxo, C1-C6 alkyl, C2 alkenyl C6, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 alkylcarbonyl, C1- alkylcarbonyloxy C6, C1-C6 alkoxycarbonyl, -NR6R7, -CONR8R9, C3-C6 cycloalkyl, C3-C6 cycloalkyloxy or C3-C6 cycloalkylmethyl; R2 represents a hydrogen or fluorine atom or a hydroxyl group, C1-C3 alkoxy or trifluoromethoxy and R3 represents a hydrogen atom, or R2 and R3 can together form a carbon-carbon bond; X represents a CHR4 group; R4 represents a hydrogen atom or, when R3 represents a hydrogen atom, R4 together with R2 can form a carbon-carbon bond; m is 1 or 2; R5 represents a 5-6 membered heteroaryl group having one or more ring nitrogen atoms as the only ring heteroatoms, where the heteroaryl group is optionally substituted by at least one substituent independently selected from halogen, cyano, C1-C6 alkyl , C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylsulfinyl, C1-C6 alkylsulphonyl, C1-C6 alkylcarbonyloxy , C1-C6 alkoxycarbonyl, -NR10R11, -CONR12R13, C3-C6 cycloalkyl, C3-C6 cycloalkyloxy or C3-C6 cycloalkylmethyl; R6 and R7 each independently represent a hydrogen atom or a C1-C6 alkyl or C3-C6 cycloalkyl group, or R6 and R7 together with the nitrogen atom to which they are attached can form an optionally substituted 4 to 7 membered saturated heterocyclic ring by halogen or hydroxy; R and R9 each independently represent a hydrogen atom or a C1-C6 alkyl group, or R8 and R9 together with the nitrogen atom to which they are attached can form a saturated 4- to 7-membered heterocyclic ring; R10 and R11 each independently represent a hydrogen atom or a C1-C6 alkyl or C3-C6 cycloalkyl group, or R10 and R11 together with the nitrogen atom to which they are attached can form an optionally substituted 4 to 7 membered saturated heterocyclic ring by halogen or hydroxy; and R12 and R13 each independently represent a hydrogen atom or a C1-C6 alkyl group, or R12 and R13 together with the nitrogen atom to which they are attached can form a saturated 4- to 7-membered heterocyclic ring; with the proviso that the compound of formula (I) is not: (3- (4-chlorophenyl) -1-piperidinyl) (1-methyl-3-propyl-1H-pyrazol-5-yl) methanone, (2- (ethylamino) -5-pyrimidinyl) (3-phenyl-1-piperidinyl) methanone, (6-amino-3-pyridinyl) (3- (2-methylphenyl) -1-piperidinyl) methanone, (2-amino-4- pyridinyl) (3- (2-methylphenyl) -1-piperidinyl) methanone, [1-ethyl-3- (1-methyl) -1H-pyrazol-5-yl] [3- (2-methylphenyl) -1-piperidinyl ] methanone, [4-methyl-2- (1-methyl) -5-pyrimidinyl] [3- (2-methylphenyl) -1-piperidinyl] methanone, [3- (2-methylphenyl) -1-piperidinyl] [2 - (4-morpholinyl) -5-pyrimidinyl] methanone, [3- (3-methylphenyl) -1-piperidinyl] (1-methyl-3-propyl-1H-pyrazol-5-yl) methanone, [3- (3 -methylphenyl) -1-piperidinyl] -2-pyridinyl-methanone, 5 - [[3- (2-methylphenyl) -1-piperidinyl] carbonyl] -2-pyridinecarbonitrile, (2-methoxy-3-pyridinyl) [3- (3-methylphenyl) -1-piperidinyl] methanone, [3- (2-methylphenyl) -1-piperidinyl] (3-propyl-1H-pyrazol-4-yl) methanone, (1-ethyl-1H-pyrazol-4 -il) [3- (3-methylphenyl) -1-piperidinyl] methanone, [1- (1-methyl ethyl) -1H-pyrazol-4-yl] (3-phenyl -1-piperidinyl) methanone, (5-methyl-1H-imidazol-2-yl) [3- (2-methylphenyl) -1-piperidinyl] methanone, [2- (1,1-dimethylethyl) -5-pyrimidinyl] [3-hydroxy-3- (2-methoxyphenyl) -1-piperidinyl] methanone, [3-hydroxy-3- (2-methoxyphenyl) -1-piperidinyl] [1- (1-methylethyl) -1H-pyrazole-5 -yl] methanone, (3- (3-chloro-2-fluorophenyl) piperidin-1-yl) (1H-imidazol-1-yl) methanone or Iodide salt of 1- (3- (3-chloro-2- fluorophenyl) piperidine-1-carbonyl) -3-methyl-1H-imidazol-3-io; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2013-08-08^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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