http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2707787-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da6012a6809db78e155927b5ba9b955d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-232 |
| filingDate | 2006-12-01^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-04-05^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e3bc6e38e6d5720bf0264f54131f22f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5381f11930643366966f98072a17453d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94ec2311355eeb05675032173546d411 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d557cdce83f5e887af09fd1dbf279bab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aaad4ffe476ca8ef100f6f295a457d13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a96aaa6da50d52020f8494c1bc5b1aa6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2f8c89c12e3770c37dec03c03286124 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_531f9392cf49467f6d5061a93f18bbfc |
| publicationDate | 2019-04-05^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2707787-T3 |
| titleOfInvention | Antibacterial analogs of 4,5-substituted aminoglycoside having multiple substituents |
| abstract | A compound having the following formula I: ** Formula ** or a stereoisomer, prodrug selected from acetate, format and benzoate derivatives of alcohol and amine functional groups and ester derivatives of carboxylic acid functional groups, or a pharmaceutically acceptable salt thereof, wherein: Q1 is azide or -NR10R11; Q2 is -NR10R12; each of Q3 and Q4 is -OR7; Q5 is H, halogen, cyano, azide, -OR8, -NR2R3, a protected amino group, or a nitrogen-containing heterocyclic radical which may include one or more additional heteroatoms selected from N, O, and S, and wherein the heterocyclic radical it is covalently attached through said nitrogen atom; each R1 is independently H or a hydroxyl protecting group; each R2 is, independently, H, an amino, C1-C12 alkyl or substituted C1-C12 alkyl protecting group; R3 is independently H, an amino, cyano, C1-C12 alkyl, substituted C1-C12 alkyl, C2-C12 alkenyl, substituted C2-C12 alkenyl, C2-C12 alkynyl, substituted C2-C12 alkynyl or - (CH2 ) n- (L1) m- (CH2) nn-E1; each R7 is independently H, a hydroxyl protecting group or - (CH2) n- (L1) m- (CH2) nn-E1; R8 is H, a protecting group of hydroxyl, C1-C12 alkyl, substituted C1-C12 alkyl, C2-C12 alkenyl, substituted C2-C12 alkenyl, C2-C12 alkynyl, substituted C2-C12 alkynyl or - (CH2) n- ( L1) m- (CH2) nn-E1; each R10 is H, C1-C12 alkyl or substituted C1-C12 alkyl; R11 is cyano, C1-C12 alkyl, substituted C1-C12 alkyl, C2-C12 alkenyl, substituted C2-C12 alkenyl, C2-C12 alkynyl, substituted C2-C12 alkynyl or - (CH2) n- (L1) m- (CH2 ) nn-E1; and R12 is C1-C12 alkyl, substituted C1-C12 alkyl or a group having formula III ** Formula ** each R6 is independently H or an amino protecting group; L1 is S, O or NJ1; L2 is CH or N; n is an integer from 1 to 8; m is 0 or 1; nn is 0 or an integer from 1 to 8, mm is 1 or 2; E1 is H, hydroxyl, halogen, cyano, -NJ1J2, C2-C12 alkenyl, substituted C2-C12 alkenyl, C2-C12 alkynyl, substituted C2-C12 alkynyl, C5-C20 aryl, substituted C5-C20 aryl, heteroaryl, substituted heteroaryl , a heterocyclic radical, a substituted heterocyclic radical, or a substituted or unsubstituted mono or polycyclic structure that may be unsaturated, partially saturated, or fully saturated and may include one or more heteroatoms selected from O, N, and S; each J1 and J2 is, independently, H, C1-C12 alkyl, substituted C1-C12 alkyl, C2-C12 alkenyl, substituted C2-C12 alkenyl, C2-C12 alkynyl, C2-C12 alkynyl, C5-C20 aryl, C5 aryl -Substituted -C20, -C (= O) -X, a heterocyclic radical or a substituted heterocyclic radical; each X is independently H, C1-C12 alkyl or substituted C1-C12 alkyl; each Z1 and Z2 is, independently, H, hydroxyl or a protected hydroxyl; and Z3 is a group having the following formula IV: ** Formula ** in which when Q2 is -N (H) C (= O) C (H) - (OH) CH2CH2NH2, then Q1 is different from -N (H) CH3 or - N (H) CH2CH3 and Q5 is different from -N (H) C (= NH) NH2 or -N (H) CH = NH2. |
| priorityDate | 2005-12-02^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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