http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2728319-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1fd3686cb239172b74cee63622184c3c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-6555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-655 |
| filingDate | 2014-09-17^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-23^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e97c8a55cc6c3233b30687dc1691cdaa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b771b4cddccbb9135c4d6f5feca5dc1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d11176530b44a8deeab573aed40435f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_718467672ea8b2a0b1179f8f4c42b10a |
| publicationDate | 2019-10-23^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2728319-T3 |
| titleOfInvention | Cortistatin analogues for the treatment of inflammatory and / or immune diseases |
| abstract | A cortistatin analog compound of the general formula (I), R1-AA1-AA2-AA3-AA4-c [Cys-AA5-Asn-XY-Trp-Lys-Thr-Z-AA6-Ser-Cys] -AA7-R2 its stereoisomers, mixtures thereof and / or its pharmaceutically acceptable salts, where: AA1 is Asp or AA2 bond is Arg or AA3 bond is Met or Ala or AA4 bond is Pro or Gly AA5 is Lys or Arg AA6 is Ser or Thr AA7 it is Lys or link X, Y, Z are the amino acids Phe, Phg, Msa, 3,4,5-trimethylphenylalanine, Msg, 3,4,5-trimethylphenylglycine and / or a dihalogenophenylalanine, diW-Phe; W is selected from the group consisting of F, Cl, Br and I; R1 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, a polymer derived from polyethylene glycol, a chelating agent and R5-CO-; R2 is selected from the group consisting of -NR3R4, -OR3 and -SR3; R3 and R4 are independently selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, and substituted aralkyl unsubstituted and a polymer; R5 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl and substituted or unsubstituted heteroarylalkyl; and with the proviso that: - At least one of the amino acids X, Y or Z is Msa, 3,4,5-trimethylphenylalanine, Msg, 3,4,5-trimethylphenylglycine and / or a dihalogenophenylalanine, diW-Phe; - If AA1 and AA2 are bonds, AA3 is Ala, AA4 is Gly, AA5 is Lys, AA6 is Thr and AA7 is a bond, then at least one of the amino acids X, Y or Z is a dihalogenophenylalanine, diW-Phe. |
| priorityDate | 2013-09-18^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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