http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2728356-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 |
| filingDate | 2016-06-27^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-23^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83c68ce9a8876c38d21a773b6867a686 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3c7319fff0f93543917445746f4b72d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb446412676caa12b72ff98b2a8d3d94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d336274c39a2958948b05cc03342233c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e102e3b5531be085364c075cfba678e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dee5b484548278d831e19f8ca1720891 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b5b95a3c3994b71b14323e32b9c9189 |
| publicationDate | 2019-10-23^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2728356-T3 |
| titleOfInvention | Polycyclic amide derivatives as CDK9 inhibitors |
| abstract | A compound of formula I: ** Formula ** in which: A is C (R5) or N; R5 is H, C1-3 alkyl, CN or halogen; R2 is 3-7 membered heterocycloalkyl or 3-7 membered cycloalkyl; optionally substituted with one to three substituents independently selected from the group consisting of R10, OR10, SR10, S (O) R10, S (O) 2R10, C (O) R10, C (O) OR10, OC (O) R10, OC (O) O R10, NH2, NH R10, N (R10) 2, NHC (O) H, NHC (O) R10, N R10C (O) H, N R10C (O) R10, NHS (O) 2 R10 , NR10S (O) 2R10, NHC (O) OR10, NR10C (O) OR10, NHC (O) NH2, NHC (O) NHR10, NHC (O) N (R10) 2, NR10C (O) NH2, NR10C (O ) NHR10, NR10C (O) N (R10) 2, C (O) NH2, C (O) NH R10, C (O) N (R10) 2, C (O) NHOH, C (O) NHOR10, C ( O) NHS (O) 2R10, C (O) NR10S (O) 2R10, S (O) 2NH2, S (O) 2NHR10, S (O) 2N (R10) 2, S (O) 2NHC (O) OR10, S (O) 2NR10C (O) OR10, C (O) H, C (O) OH, OH, CN, NO2, F, Cl, Br and I ;, where one or more CH2 groups of the ring can be optionally replaced by a corresponding number of -C (O) groups, one or more sulfur or ring nitrogen atoms may optionally be oxidized to form S-oxides or N-oxides; R10, at each occurrence, is independently selected from the group consisting of a 3- to 6-membered cycloalkyl or heterocycloalkyl group, C1-6 alkyl, -O-C1-6 alkyl, C1-6 alkyl-O-C1-6 alkyl, NH2, C (O) NH2, C (O) H, C (O) OH, OH, CN, NO2, F, Cl, Br and I; wherein two R10 groups together with the atoms to which they are attached can form a 3-6 membered cycloalkyl or heterocycloalkyl group; and each of the R10 alkyl, cycloalkyl and heterocycloalkyl groups mentioned above may be further substituted with one or two substituents independently selected from CN, OH, halogen, C1-3 alkyl, -O-C1-3 alkyl, NH2, NH-alkyl C1-3, and NHC (O) -C1-3 alkyl. R4 is ** Formula ** where X and Y, together with the atoms to which they are attached, form a 5- to 7-membered heterocycloalkyl ring which, in addition to the bridging nitrogen, can contain one or two heteroatoms selected from N, O and S, whose ring can be saturated or partially saturated; wherein one or two groups of CH2 rings may optionally be replaced by a corresponding number of -C (O) groups, one or more sulfur or nitrogen atoms in the ring may optionally be oxidized to form S-oxides or N-oxides and wherein the ring can be substituted on a carbon ring by one or two R10 substituents or on a nitrogen ring by an R12 substituent. J is N or CR11; and R11 is H, C1-3 alkyl; R12 at each occurrence is independently selected from the group consisting of a 3-6 membered cycloalkyl or heterocycloalkyl group, C1-6 alkyl, C1-6 alkyl -O- C1-6 alkyl, C (O) NH2, C (O) H; wherein the R12 alkyl, cyclo alkyl and heterocycloalkyl group can be further substituted with one or two substituents independently selected from CN, OH and halogen, C1-3 alkyl, NH2, and NH-C1-3 alkyl, NHC (O) -alkyl C1-3, or pharmaceutically acceptable salts thereof. |
| priorityDate | 2015-06-29^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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