http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2760974-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c1ee19e6efdf91c1bf88bde9e9845ef |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 |
| filingDate | 2016-07-28^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-18^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62e037a8a900e878bd1e9d7372653077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e908361c478b972e28978ed5be137029 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58eea9cb72a6c8da6962fc1f35fe22a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc17392ca7cb3999c32ec3af595cd211 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b7a8478c01d22080e47f4283aab229d |
| publicationDate | 2020-05-18^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2760974-T3 |
| titleOfInvention | Substituted amide derivatives that have multimodal activity against pain |
| abstract | Compound of general formula (I): ** Formula ** where m is 1 or 2; n is 0, 1 or 2; p is 0, 1 or 2; W is nitrogen or carbon; X is a bond, -C (RxRx ') -, C = O, -C (O) O- or -O-; wherein Rx is selected from halogen, -OR15, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl; Rx 'is selected from hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl; R15 is selected from hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl; R1 is selected from substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heterocyclyl substituted; wherein said cycloalkyl, aryl or heterocyclyl in R1, if substituted, is substituted by one or more substituents selected from halogen, -R11, -OR11, -NO2, -NR11R11 '' ', NR11C (O) R11', - NR11S (O) 2R11 ', -S (O) 2NR11R11', -NR11C (O) NR11'R11 '', -SR11, -S (O) R11, S (O) 2R11, -CN, haloalkyl, haloalkoxy, -C (O) OR11, -C (O) NR11R11 ', -NR11S (O) 2NR11'R11' 'and C (CH3) 2OR11; additionally, non-aromatic cycloalkyl or heterocyclyl in R1, if substituted, may also be substituted by ** Formula ** or = O; wherein the alkyl, alkenyl or alkynyl in R1, if substituted, is substituted by one or more substituents selected from -OR11, halogen, -CN, haloalkyl, haloalkoxy, -SR11, -S (O) R11 and -S (O ) 2R11; where R11, R11 'and R11' 'are independently selected from hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl and unsubstituted C2-6 alkynyl; and where R11 '' 'is selected from hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, unsubstituted C2-6 alkynyl and -Boc; R2 is selected from hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, and substituted heterocyclyl or not substituted; wherein said cycloalkyl, aryl or heterocyclyl in R2, if substituted, is substituted by one or more substituents selected from halogen, -R12, -OR12, -NO2, -NR12R12 '' ', NR12C (O) R12', - NR12S (O) 2R12 ', -S (O) 2NR12R12', -NR12C (O) NR12'R12 '', -SR12, -S (O) R12, S (O) 2R12, -CN, haloalkyl, haloalkoxy, -C (O) OR12, -C (O) NR12R12 ', -NR12S (O) 2NR12'R12' 'and C (CH3) 2OR12; additionally, the non-aromatic cycloalkyl or heterocyclyl in R2, if substituted, may also be substituted by ** Formula ** or = O; where the alkyl, alkenyl or alkynyl in R2, if substituted, is substituted by one or more substituents selected from -OR12, halogen, -CN, haloalkyl, haloalkoxy, -SR12, -S (O) R12 and -S (O) 2R12; wherein R12, R12 'and R12' 'are independently selected from hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, and unsubstituted C2-6 alkynyl; and where R12 '' 'is selected from hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, unsubstituted C2-6 alkynyl and -Boc; R3 is selected from substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl substituted, -NR9R9 'and -CH2OR9; wherein R9 and R9 'are independently selected from hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted cycloalkyl, substituted aryl or unsubstituted and substituted or unsubstituted heterocyclyl; R4 and R4 'are independently selected from substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl, alternatively, R4 and R4' may form together with the carbon atom to which a ring of formula (A) is attached (where "-" denotes the carbon atom to which R4 and R4 'are attached): ** Formula ** where q is 0 or 1; r is 0, 1 or 2; Y is -CH2-, -N (Ry) -, -S- or -O-; R8 and R8 'are independently selected from hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl; alternatively, R8 and R8 ', taken together with the carbon atom to which they are attached, can form a C3-6 cycloalkyl; Ry is selected from hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl; R5 and R5 'are independently selected from hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, -CH2OR10 and -C (O) OR10; wherein R10 is selected from hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl; R6 and R6 'are independently selected from hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl; R7 and R7 'are independently selected from hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl; and where ** Formula ** |
| priorityDate | 2015-07-29^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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