http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2767973-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1916cbc3943c56f9c2e5daf9c5b37a4a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0459 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2009-02-27^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-19^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08fc51f4e12ff700d49e8c3d108da876 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2eaea4516d4217e571fd6389e19b61da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdaf9414c9347500398874e32e2e4fb1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7725b8765cc94d8db256c50d6f08db6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c72086e6183ba3f0c0b05a91ecfbe57f |
| publicationDate | 2020-06-19^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2767973-T3 |
| titleOfInvention | Contrast agents for applications involving perfusion imaging |
| abstract | A method for imaging at least a part of the brain or at least a part of the central nervous system in a human subject, comprising: administering to the subject a contrast agent having the structure ** Formula ** wherein J is selected of N (R27), S, O, C (= O), C (= O) O, NHCH2CH2O, a bond, or C (= O) N (R27); K and L, when present, are independently selected from hydrogen, alkoxyalkyl, alkyloxy, aryl, alkyl, heteroaryl, and an imaging moiety, each of which is optionally substituted; M is selected from alkoxyalkyl and alkyloxy, each of which is optionally substituted, or L and M, together with the atom to which they are attached, form a ring, optionally substituted; Q is halo or haloalkyl; n is 0, 1, 2 or 3; R21, R22, R23, R24, R25, R26, and R27 are independently selected from hydrogen, alkyl, optionally substituted, and an imaging moiety; R29 is alkyl, optionally substituted; and Y is selected from carbon and oxygen, provided that when Y is oxygen, K and L are absent and M is optionally substituted alkoxyalkyl, wherein at least one imaging moiety is present in Formula (II); and wherein said optional substituent is selected from one or more of the following: alkyl, alkenyl, cycloalkyl, alkylaryl, alkylcarbonyl, aryl, arylalkyl, alkylarylalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, heteroalkyl, heterocyclyl, heterocyclylalkyl, amino, thio, - OH, phosphate, -CO2H, = O, halo, trifluoromethyl, nitro, cyano, ester, aldehyde, amide, keto, azide, sulfhydryl, imino, phosphonate, phosphinate, carbonyl, carboxyl, silyl, ether, alkylthio, sulfonyl, sulfonamide or an image rest; optionally, wherein K and L, when present, are independently selected from hydrogen, alkoxyalkyl, alkyloxy, aryl, heteroaryl, and an imaging moiety, each of which is optionally substituted; or, optionally, where J is O and R29 is C1-C6 alkyl; or, optionally, where R29 is tert-butyl; or, optionally, where K, L, or M is alkoxyalkyl, optionally substituted with an imaging moiety; or optionally where M is alkoxyalkyl, optionally substituted with an imaging moiety; and scanning the subject using diagnostic images to produce an image of at least a portion of the brain or at least a portion of the central nervous system. |
| priorityDate | 2008-02-29^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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