http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2768602-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_442519b1c08867cccfb1e54fa4fc6654 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2013-03-15^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-23^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3477da616d7f2fc2f6e9b5669cd4ae7 |
| publicationDate | 2020-06-23^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2768602-T3 |
| titleOfInvention | Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation |
| abstract | A compound of Formula I: ** Formula ** in which: Het is an 8, 9 or 10 membered bicyclic heteroaryl in which at least one ring atom is an N and said heteroaryl is unsubstituted or substituted with one or more Ra substituents; wherein each Ra is independently hydroxyl, halo, amino, cyano, nitro, C1-4 alkyl, C1-12 haloalkyl, C1-4 alkoxy, or -C1-4 haloalkoxy; X is -CH2-, -CH2CH2- or -CH2O-; one of W and Y is NH and the other is O or NH; Z is O or S; R1 is -NRbRc; guanidino; a 5- or 6-membered monocyclic heteroaryl in which at least one ring atom is an N and said heteroaryl is unsubstituted or substituted with one or more Rd substituents; or a 3- to 7-membered monocyclic heterocycloalkyl, wherein at least one ring atom is an N, and said heterocycloalkyl is unsubstituted or substituted with one or more Re substituents; wherein Rb and Rc are each independently H or C1-4 alkyl; each Rd is independently hydroxyl, halo, amino, cyano, nitro, C1-4 alkyl, C1-12 haloalkyl, C1-4 alkoxy or -C1-4 haloalkoxy; and each Re is independently hydroxyl, halo, amino, cyano, nitro, C1-4 alkyl, C1-12 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, -C (O) C1-4 alkyl or -CO2C1-4alkyl ; n is 2; R2 is absent or is hydroxy, methoxy, or trifluoromethoxy; and R3 is C1-6 alkyl, C1-6 alkoxy, or C3-8 cycloalkoxy, wherein said cycloalkoxy is unsubstituted or is substituted with one or more substituents selected from the group consisting of hydroxyl, halo, amino, cyano, nitro, alkyl C1-4, C1-12 haloalkyl, C1-4 alkoxy and C1-4 haloalkoxy; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2012-03-28^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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