abstract |
An antigen recognition construct that is a T cell receptor (TCR), comprising (i) an alpha chain variable region with CDR1, CDR2 and CDR3 comprising an amino acid sequence shown in SEQ ID NO: 40, 41 and 1 respectively; and comprising (ii) a beta chain variable region with CDR1, CDR2 and CDR3 comprising an amino acid sequence shown in SEQ ID NOs: 46, 47 and 4 respectively; wherein said TCR specifically binds to the MAGE-A1 antigen. |