| abstract |
A compound of formula (I): **(See formula)** or a pharmaceutically acceptable salt, tautomer, isotopologue or stereoisomer thereof, wherein: X is CN or CF3; L is (C1-4 alkyl); R1 is substituted or unsubstituted heteroalkyl; and R2 is substituted or unsubstituted cycloalkyl; where, when a group is substituted, the group is substituted with halogen, alkyl, hydroxyl, alkoxy, alkoxyalkyl, amino, alkylamino, carboxy, nitro, cyano, thiol, thioether, imine, imide, amidine, guanidine, enamine, aminocarbonyl, acylamino , phosphonate, phosphine, thiocarbonyl, sulfonyl, sulfone, sulfonamide, ketone, aldehyde, ester, urea, urethane, oxime, hydroxylamine, alkoxyamine, aralkoxyamine, N-oxide, hydrazine, hydrazide, hydrazone, azide, isocyanate, isothiocyanate, cyanate, thiocyanate , oxo, B(OH)2, O(alkyl)aminocarbonyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, aryloxy, aralkyloxy, heterocyclyloxy, or heterocyclylalkoxy. |