http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2813877-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2308d2f079e23c4a316e143f69b01946 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 |
| filingDate | 2014-08-28^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-25^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_569a442160fa563a0e23c5ffaa4d92de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a85ee3cba9ab9562c20c82c3977b8885 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54bd7e36b660fefc09a06f82129535ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_805cf98e16c446203469519797cf3ddd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4c29249ee1d7a0c28c51750e41adeb3 |
| publicationDate | 2021-03-25^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2813877-T3 |
| titleOfInvention | Gene expression flags predictive of a subject's response to a multikinase inhibitor and methods of using the same |
| abstract | A method of determining the sensitivity of a subject to a multikinase inhibitor comprising measuring the expression profile of a panel of gene markers in a biological sample from the subject, wherein the panel of gene markers consists of one or more markers selected from the group consisting of SEC14L2, H6PD, TMEM140, SLC2A5, ACTA1, IRF8, STAT2 and UGT2A1, comparing the expression profile of the panel with a predetermined expression profile, where the sensitivity of the subject is determined based on the comparison between the expression profile of the panel of gene markers and the predetermined expression profile, where it is determined that the subject is sensitive to the treatment with multikinase inhibitor when the expression profile of any of the marker genes is within the predetermined expression profile, or when the profile of expression of a panel of gene markers is similar to or lower than the predetermined expression profile, where it is determined that the subject is not responsive to multikinase inhibitor treatment when the expression profile of a panel of gene markers is not within the predetermined expression profile, or when the expression profile of a panel of gene markers is higher than the predetermined expression profile, and wherein the multikinase inhibitor targets vascular endothelial growth factor (VEGF) mediated angiogenesis and blocks the extracellular signal-regulated kinase (ERK) kinase (MEK) / ERK cascade. |
| priorityDate | 2013-08-28^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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