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filingDate 2013-12-27^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-04-05^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2021-04-05^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2816550-T3
titleOfInvention Pre-treatment method for antithrombin III to undergo a Limulus test
abstract A method for measuring endotoxin contained in antithrombin III, a method comprising subjecting the antithrombin III to heat treatment or acid treatment, and subjecting the treated antithrombin III to the limulus test, in which heat treatment and acid treatment are carried out in the joint presence of a pretreatment agent containing a divalent metal salt, where antithrombin III is an injectable preparation of antithrombin III or a solution containing antithrombin III at a concentration of 50 Units / mL or greater than 50 Units / mL, where a target substance of the limulus test is endotoxin, and where the heat treatment and the acid treatment are performed in an aqueous medium and the divalent metal salt provides a divalent metal ion by dissolution in the aqueous medium.
priorityDate 2012-12-28^^<http://www.w3.org/2001/XMLSchema#date>
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