http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2887578-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40765ca9a78b54a8a76f781d159ad145 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2014-02-28^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-23^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6928d8a4792fe0dda19e4c22a6e30f07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff0103650c9db3e0237aef57519ba84e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_952982885aec286344cef45bcea29a7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73b79fbba892f0e75c1e70a81a31093d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35a66383b026e06e91c7768b4ef38db2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bee7cbf96bb14e7ef3471aa3c3c0482 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11c617b71db7a40531c948f34f4342eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3511a3ad994356da7e65e7c2f31af2c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0c20f623041ca949d60791fd7f63ca0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c50d8530e7558774ec374918e4af0cc4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32efedc0af12138ab475a9cb2c228989 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12285d171484b8db8753db5bfc23bdae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f635bb33ac885bbd32a2e3f7b89639dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_357f5425646e950ddfaf5b442ebcb304 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab63773787e0f55519bdbaeb1898a9e5 |
| publicationDate | 2021-12-23^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2887578-T3 |
| titleOfInvention | Amide compounds for the treatment of HIV infections |
| abstract | a compound of formula IIId: **(See formula)** wherein A1 is CH, C-Z3 or nitrogen; A2 is CH or nitrogen; R1 is 6-12 membered aryl, 5-12 membered heteroaryl or 3-12 membered heterocycle, wherein any 6-12 membered aryl, 5-12 membered heteroaryl or 3-12 membered heterocycle of R1 is optionally substituted with 1, 2, 3, 4 or 5 Z4 groups, where the Z4 groups are the same or different; each R3a and R3b is independently H or (C1-C3)alkyl; Z1 is **(See formula)** optionally substituted with 1, 2, 3, 4 or 5 Z1a or Z1b, where the Z1a and Z1b groups are the same or different; each Z1a is independently (C3-C7) carbocycle, 5-12 membered heteroaryl, 3-12 membered heterocycle, halogen, -CN, -ORn1, -OC(O)Rp1, -OC(O)NRq1Rr1, -SRn1, -S(O)Rp1, -S(O)2OH, -S(O)2Rp1, -S(O)2NRq1Rr1, -NRq1Rr1, -NRn1CORp1, -NRn1CO2Rp1, -NRn1CONRq1Rr1, -NRn1S(O)2Rp1, -NRn1S( O)2ORp1, -NRn1S(O)2NRq1Rr1, -C(O)Rn1, -C(O)ORn1, -C(O)NRq1RR1 and -S(O)2NRn1CORp1, where any carbocycle (C3-C7), heteroaryl 5-12 membered and 3-12 membered heterocycle of Z1a is optionally substituted with 1, 2, 3, 4 or 5 groups Z1c or Z1d, wherein the groups Z1c and Z1d are the same or different; each Z1b is independently (C1-C8) alkyl optionally substituted with 1, 2, 3, 4 or 5 halogens, which are the same or different; each Z1c is independently halogen, -CN, -OH, -NH2, -C(O)NRq2Rr2, or (C1-C8)heteroalkyl; each Z1d is independently (C1-C8)alkyl or (C1-C8)haloalkyl; each Rn1 is independently H, (C1-C8)alkyl, (C3-C7)carbocycle, 3-7 membered heterocycle, or 5-6 membered monocyclic heteroaryl, where any (C3-C7)carbocycle, 3- 7 membered, or 5-6 membered monocyclic heteroaryl of Rn1 is optionally substituted with 1, 2, 3, 4 or 5 groups Z1c or Z1d, wherein the groups Z1c and Z1d are the same or different, and wherein any (C1 -C8) of Rn1 is optionally substituted with 1, 2, 3, 4 or 5 Z1c groups, where the Z1c groups are the same or different; each Rp1 is independently (C1-C8)alkyl, (C3-C7)carbocycle, 3-7 membered heterocycle, or 5-6 membered monocyclic heteroaryl, where any (C3-C7)carbocycle, 3-7 membered heterocycle , or 5-6 membered monocyclic heteroaryl of Rp1 is optionally substituted with 1, 2, 3, 4 or 5 Z1c or Z1d groups, where the Z1c and Z1d groups are the same or different, and where any (C1-C8 ) of Rp1 is optionally substituted with 1, 2, 3, 4 or 5 Z1c groups, where the Z1c groups are the same or different; each Rq1 and Rr1 is independently H, (C1-C8)alkyl, (C3-C7)carbocycle, 3-7 membered heterocycle, or 5-6 membered monocyclic heteroaryl, wherein any (C3-C7)carbocycle, (C3-C7)heterocycle 3-7 membered, or 5-6 membered monocyclic heteroaryl of Rq1 or Rr1 is optionally substituted with 1, 2, 3, 4 or 5 groups Z1c or Z1d, wherein the groups Z1c and Z1d are the same or different, and wherein any (C1-C8) alkyl of Rq1 or Rr1 is optionally substituted with 1, 2, 3, 4 or 5 Z1c groups, where the Z1c groups are the same or different, or Rq1 and Rr1 together with the nitrogen to which they are attached form a 5, 6 or 7 membered heterocycle, wherein the 5, 6 or 7 membered heterocycle is optionally substituted with 1, 2, 3, 4 or 5 Z1c or Z1d groups, wherein the Z1c and Z1d groups are the same or different ; each Rq2 and Rr2 is independently H, (C1-C8)alkyl, (C3-C7)carbocycle or Rq2 and Rr2 together with the nitrogen to which they are attached form a 5-, 6- or 7-membered heterocycle; Z2 is 6-12 membered aryl, 5-12 membered C-linked heteroaryl, or 3-12 membered C-linked heterocycle wherein any 6-12 membered aryl, 5-12 membered C-linked heteroaryl, or 3-12 membered C-linked heterocycle of Z2 is optionally substituted with 1, 2, 3, 4 or 5 groups Z2b or Z2c, wherein the groups Z2b and Z2c are the same or different; each Z2b is independently oxo, (C1-C4)alkyl, (C1-C4)heteroalkyl, or (C1-C4)haloalkyl each Z2c is independently oxo, halogen, -CN, -ORn4, -OC(O)Rp4, -OC( O)NRq4Rr4, -SRn4, -S(O)Rp4, -S(O)2OH, -S(O)2Rp4, -S(O)2NRq4Rr4, -NRq4Rr4, -NRn4CORp4, -NRn4CO2Rp4 -NRn4CONRq4Rr4, -NRn4S(O )2Rp4 -NRn4S(O)2ORp4, -NRn4S(O)2NRq4Rr4 -NO2, -C(O)Rn4, -C(O)ORn4, or -C(O)NRq4Rr4; each Rn4 is independently H, (C1-C4)alkyl, (C1-C4)haloalkyl or (C1-C4)heteroalkyl; each Rp4 is independently (C1-C8)alkyl, (C1-C4)haloalkyl, or (C1-C4)heteroalkyl; each Rq4 and Rr4 is independently H, (C1-C4)alkyl, (C1-C4)haloalkyl or (C1-C4)heteroalkyl; each Z3 is independently a (C1-C4)heteroalkyl; each Z4 is independently oxo, (C1-C8)alkyl, (C3-C7)carbocycle, halogen, -CN, -ORn5, -NRq5Rr5, -NRn5CORp5, -NRn5CO2Rp5, -C(O)Rn5, -C(O)ORn5 , or -C(O)NRq5Rr5, where any (C3-C7) carbocycle or (C1-C8) alkyl of Z4 is optionally substituted with 1, 2, 3, 4 or 5 Z4a groups, where the Z4a groups are the same or different; each Z4a is independently halogen, -CN, or -ORn6; each Rn5, Rp5, Rq5, Rr5 and Rn6 is independently H or (C1-C4)alkyl; each Z5 is independently halogen, which may be the same or different; and n is 0, 1, 2 or 3; or a compound selected from **(See formula)** or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2013-03-01^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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